Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana

Proteins that specifically interact with mRNAs orchestrate mRNA processing steps all the way from transcription to decay. Thus, these RNA-binding proteins represent an important control mechanism to double check which proportion of nascent pre-mRNAs is ultimately available for translation into disti...

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Autores principales: Lewinski, Martin, Köster, Tino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122672/
http://dx.doi.org/10.1007/978-3-319-92967-5_5
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author Lewinski, Martin
Köster, Tino
author_facet Lewinski, Martin
Köster, Tino
author_sort Lewinski, Martin
collection PubMed
description Proteins that specifically interact with mRNAs orchestrate mRNA processing steps all the way from transcription to decay. Thus, these RNA-binding proteins represent an important control mechanism to double check which proportion of nascent pre-mRNAs is ultimately available for translation into distinct proteins. Here, we discuss recent progress to obtain a systems-level understanding of in vivo RNA–protein interactions in the reference plant Arabidopsis thaliana using protein-centric and RNA-centric methods as well as combined protein binding site and structure probing.
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spelling pubmed-71226722020-04-06 Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana Lewinski, Martin Köster, Tino Systems Biology Article Proteins that specifically interact with mRNAs orchestrate mRNA processing steps all the way from transcription to decay. Thus, these RNA-binding proteins represent an important control mechanism to double check which proportion of nascent pre-mRNAs is ultimately available for translation into distinct proteins. Here, we discuss recent progress to obtain a systems-level understanding of in vivo RNA–protein interactions in the reference plant Arabidopsis thaliana using protein-centric and RNA-centric methods as well as combined protein binding site and structure probing. 2018-08-30 /pmc/articles/PMC7122672/ http://dx.doi.org/10.1007/978-3-319-92967-5_5 Text en © Springer International Publishing AG, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Lewinski, Martin
Köster, Tino
Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title_full Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title_fullStr Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title_full_unstemmed Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title_short Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
title_sort systems approaches to map in vivo rna–protein interactions in arabidopsis thaliana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122672/
http://dx.doi.org/10.1007/978-3-319-92967-5_5
work_keys_str_mv AT lewinskimartin systemsapproachestomapinvivornaproteininteractionsinarabidopsisthaliana
AT kostertino systemsapproachestomapinvivornaproteininteractionsinarabidopsisthaliana

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