Cargando…

ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk

BACKGROUND: A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more freque...

Descripción completa

Detalles Bibliográficos
Autores principales: Hallet, Edouard, Flamand, Claude, Rousset, Dominique, Bonifay, Timothée, Fritzell, Camille, Matheus, Séverine, Dueymes, Maryvonne, Ntab, Balthazar, Nacher, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122809/
https://www.ncbi.nlm.nih.gov/pubmed/32208419
http://dx.doi.org/10.1371/journal.pntd.0008193
_version_ 1783515497683222528
author Hallet, Edouard
Flamand, Claude
Rousset, Dominique
Bonifay, Timothée
Fritzell, Camille
Matheus, Séverine
Dueymes, Maryvonne
Ntab, Balthazar
Nacher, Mathieu
author_facet Hallet, Edouard
Flamand, Claude
Rousset, Dominique
Bonifay, Timothée
Fritzell, Camille
Matheus, Séverine
Dueymes, Maryvonne
Ntab, Balthazar
Nacher, Mathieu
author_sort Hallet, Edouard
collection PubMed
description BACKGROUND: A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status. METHODS: A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016. Health insurance information was recorded at delivery, which allowed separating women in: undocumented foreigners, precarious but with residence permit, and non-precarious. RESULTS: A total of 6654 women were included. Among them 1509 (22,7%) had confirmed ZIKV infection. Most women were precarious (2275/3439) but the proportion of precarious women was significantly greater in ZIKV-confirmed 728/906 (80.4%) than the ZIKV-negatives 1747/2533 (69.0%), p<0.0001. There were 1142 women classified as non-precarious, 1671 were precarious legal residents, and 1435 were precarious and undocumented. Precariousness and undocumented status were associated with a higher prevalence of ZIKV during pregnancy (adjusted prevalence ratio = 1.59 (95%CI = 1.29–1.97), p<0.0001), (adjusted prevalence ratio = 1.5 (95%CI = 1.2–1.8), p<0.0001), respectively. CONCLUSIONS: These results illustrate that in French Guiana ZIKV transmission disproportionately affected the socially vulnerable pregnant women, presumably because of poorer housing conditions, and lack of vector control measures in poor neighborhoods.
format Online
Article
Text
id pubmed-7122809
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-71228092020-04-09 ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk Hallet, Edouard Flamand, Claude Rousset, Dominique Bonifay, Timothée Fritzell, Camille Matheus, Séverine Dueymes, Maryvonne Ntab, Balthazar Nacher, Mathieu PLoS Negl Trop Dis Research Article BACKGROUND: A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status. METHODS: A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016. Health insurance information was recorded at delivery, which allowed separating women in: undocumented foreigners, precarious but with residence permit, and non-precarious. RESULTS: A total of 6654 women were included. Among them 1509 (22,7%) had confirmed ZIKV infection. Most women were precarious (2275/3439) but the proportion of precarious women was significantly greater in ZIKV-confirmed 728/906 (80.4%) than the ZIKV-negatives 1747/2533 (69.0%), p<0.0001. There were 1142 women classified as non-precarious, 1671 were precarious legal residents, and 1435 were precarious and undocumented. Precariousness and undocumented status were associated with a higher prevalence of ZIKV during pregnancy (adjusted prevalence ratio = 1.59 (95%CI = 1.29–1.97), p<0.0001), (adjusted prevalence ratio = 1.5 (95%CI = 1.2–1.8), p<0.0001), respectively. CONCLUSIONS: These results illustrate that in French Guiana ZIKV transmission disproportionately affected the socially vulnerable pregnant women, presumably because of poorer housing conditions, and lack of vector control measures in poor neighborhoods. Public Library of Science 2020-03-24 /pmc/articles/PMC7122809/ /pubmed/32208419 http://dx.doi.org/10.1371/journal.pntd.0008193 Text en © 2020 Hallet et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hallet, Edouard
Flamand, Claude
Rousset, Dominique
Bonifay, Timothée
Fritzell, Camille
Matheus, Séverine
Dueymes, Maryvonne
Ntab, Balthazar
Nacher, Mathieu
ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title_full ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title_fullStr ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title_full_unstemmed ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title_short ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk
title_sort zika virus infection in pregnant women in french guiana: more precarious-more at risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122809/
https://www.ncbi.nlm.nih.gov/pubmed/32208419
http://dx.doi.org/10.1371/journal.pntd.0008193
work_keys_str_mv AT halletedouard zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT flamandclaude zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT roussetdominique zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT bonifaytimothee zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT fritzellcamille zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT matheusseverine zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT dueymesmaryvonne zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT ntabbalthazar zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk
AT nachermathieu zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk