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Care of the Critically Ill Pediatric Sickle Cell Patient

Sickle cell disease is the most common inherited disease in the United States. Through the effects of hemolysis and vaso-occlusion, it has the potential to incite critical illness involving multiple organ systems. Children with sickle cell disease are at risk of multiple types of shock resulting in...

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Autores principales: Rosanwo, Tolulope, McArthur, Jennifer A., Archer, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122989/
http://dx.doi.org/10.1007/978-3-030-01322-6_6
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author Rosanwo, Tolulope
McArthur, Jennifer A.
Archer, Natasha
author_facet Rosanwo, Tolulope
McArthur, Jennifer A.
Archer, Natasha
author_sort Rosanwo, Tolulope
collection PubMed
description Sickle cell disease is the most common inherited disease in the United States. Through the effects of hemolysis and vaso-occlusion, it has the potential to incite critical illness involving multiple organ systems. Children with sickle cell disease are at risk of multiple types of shock resulting in a need for ICU care. Our youngest patients with sickle cell disease are at highest risk of infection due to lack of splenic function, and this can present with septic shock. Hypovolemic shock can occur secondary to severe acute anemia as seen with splenic sequestration or a delayed transfusion reaction. As one ages, the risk of cardiac dysfunction – diastolic and systolic dysfunction as well as pulmonary hypertension – can result in cardiogenic shock. In addition to shock, patients with sickle cell disease are at risk for respiratory failure from acute chest syndrome as well as acute neurologic deterioration from stroke. For these reasons, critical care physicians must be familiar with the unique management of sickle cell complications in order to provide the best possible care for this vulnerable population.
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spelling pubmed-71229892020-04-06 Care of the Critically Ill Pediatric Sickle Cell Patient Rosanwo, Tolulope McArthur, Jennifer A. Archer, Natasha Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient Article Sickle cell disease is the most common inherited disease in the United States. Through the effects of hemolysis and vaso-occlusion, it has the potential to incite critical illness involving multiple organ systems. Children with sickle cell disease are at risk of multiple types of shock resulting in a need for ICU care. Our youngest patients with sickle cell disease are at highest risk of infection due to lack of splenic function, and this can present with septic shock. Hypovolemic shock can occur secondary to severe acute anemia as seen with splenic sequestration or a delayed transfusion reaction. As one ages, the risk of cardiac dysfunction – diastolic and systolic dysfunction as well as pulmonary hypertension – can result in cardiogenic shock. In addition to shock, patients with sickle cell disease are at risk for respiratory failure from acute chest syndrome as well as acute neurologic deterioration from stroke. For these reasons, critical care physicians must be familiar with the unique management of sickle cell complications in order to provide the best possible care for this vulnerable population. 2018-10-10 /pmc/articles/PMC7122989/ http://dx.doi.org/10.1007/978-3-030-01322-6_6 Text en © Springer International Publishing 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Rosanwo, Tolulope
McArthur, Jennifer A.
Archer, Natasha
Care of the Critically Ill Pediatric Sickle Cell Patient
title Care of the Critically Ill Pediatric Sickle Cell Patient
title_full Care of the Critically Ill Pediatric Sickle Cell Patient
title_fullStr Care of the Critically Ill Pediatric Sickle Cell Patient
title_full_unstemmed Care of the Critically Ill Pediatric Sickle Cell Patient
title_short Care of the Critically Ill Pediatric Sickle Cell Patient
title_sort care of the critically ill pediatric sickle cell patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122989/
http://dx.doi.org/10.1007/978-3-030-01322-6_6
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