Bispecific Antibodies for Diagnostic Applications

Bispecific monoclonal antibodies (BsMAb) are unique engineered macromolecules that have two different pre-determined binding specificities. Their ability to simultaneously bind to a specific antigen and a given detection moiety enables them to function as excellent bifunctional immunoprobes in diagn...

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Autores principales: Parashar, Archana, Sarkar, Susmita, Ganguly, Advaita, Sharma, Sai Kiran, Suresh, Mavanur R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123020/
http://dx.doi.org/10.1007/978-3-642-20910-9_19
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author Parashar, Archana
Sarkar, Susmita
Ganguly, Advaita
Sharma, Sai Kiran
Suresh, Mavanur R.
author_facet Parashar, Archana
Sarkar, Susmita
Ganguly, Advaita
Sharma, Sai Kiran
Suresh, Mavanur R.
author_sort Parashar, Archana
collection PubMed
description Bispecific monoclonal antibodies (BsMAb) are unique engineered macromolecules that have two different pre-determined binding specificities. Their ability to simultaneously bind to a specific antigen and a given detection moiety enables them to function as excellent bifunctional immunoprobes in diagnostic assays. BsMAb are being exploited for the development of simple, rapid, and highly sensitive immunoassays for diagnosis of bacterial and viral infectious diseases. This chapter describes the use of BsMAb for the detection of Mycobacterium tuberculosis, Escherichia coli O157:H7, Bordetella pertussis, Severe Acute Respiratory Syndrome coronavirus, and Dengue virus. Further, BsMAb have been utilized for diagnosis of various types of cancers. The use of BsMAb in detection of prostate cancer and in cancer diagnostic imaging is also discussed.
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spelling pubmed-71230202020-04-06 Bispecific Antibodies for Diagnostic Applications Parashar, Archana Sarkar, Susmita Ganguly, Advaita Sharma, Sai Kiran Suresh, Mavanur R. Bispecific Antibodies Article Bispecific monoclonal antibodies (BsMAb) are unique engineered macromolecules that have two different pre-determined binding specificities. Their ability to simultaneously bind to a specific antigen and a given detection moiety enables them to function as excellent bifunctional immunoprobes in diagnostic assays. BsMAb are being exploited for the development of simple, rapid, and highly sensitive immunoassays for diagnosis of bacterial and viral infectious diseases. This chapter describes the use of BsMAb for the detection of Mycobacterium tuberculosis, Escherichia coli O157:H7, Bordetella pertussis, Severe Acute Respiratory Syndrome coronavirus, and Dengue virus. Further, BsMAb have been utilized for diagnosis of various types of cancers. The use of BsMAb in detection of prostate cancer and in cancer diagnostic imaging is also discussed. 2011-07-01 /pmc/articles/PMC7123020/ http://dx.doi.org/10.1007/978-3-642-20910-9_19 Text en © Springer-Verlag Berlin Heidelberg 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Parashar, Archana
Sarkar, Susmita
Ganguly, Advaita
Sharma, Sai Kiran
Suresh, Mavanur R.
Bispecific Antibodies for Diagnostic Applications
title Bispecific Antibodies for Diagnostic Applications
title_full Bispecific Antibodies for Diagnostic Applications
title_fullStr Bispecific Antibodies for Diagnostic Applications
title_full_unstemmed Bispecific Antibodies for Diagnostic Applications
title_short Bispecific Antibodies for Diagnostic Applications
title_sort bispecific antibodies for diagnostic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123020/
http://dx.doi.org/10.1007/978-3-642-20910-9_19
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AT sharmasaikiran bispecificantibodiesfordiagnosticapplications
AT sureshmavanurr bispecificantibodiesfordiagnosticapplications

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