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Dried Plasma
Dried plasma provides an alternative for early plasma transfusion in the resuscitation of hemorrhagic shock in environments where fresh frozen plasma is not immediately available. It is produced by freeze-drying or spray-drying liquid or thawed plasma. It is shelf-stable for prolonged periods, can b...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123378/ http://dx.doi.org/10.1007/978-3-030-20820-2_8 |
| _version_ | 1783515624761196544 |
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| author | Zaza, Mouayyad Kalkwarf, Kyle J. Holcomb, John B. |
| author_facet | Zaza, Mouayyad Kalkwarf, Kyle J. Holcomb, John B. |
| author_sort | Zaza, Mouayyad |
| collection | PubMed |
| description | Dried plasma provides an alternative for early plasma transfusion in the resuscitation of hemorrhagic shock in environments where fresh frozen plasma is not immediately available. It is produced by freeze-drying or spray-drying liquid or thawed plasma. It is shelf-stable for prolonged periods, can be stored at room temperature, and is easy to transport, reconstitute, and administer. It was widely used in WWII but fell out of favor due to the risk of infectious disease transmission. The German and French experiences with lyophilized plasma are the most extensive and show a good track record of efficacy and safety. Recent studies show many beneficial effects of dried plasma in the treatment of shock in large animal models. Currently, no FDA-licensed product is available in the USA, but several are under development. |
| format | Online Article Text |
| id | pubmed-7123378 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71233782020-04-06 Dried Plasma Zaza, Mouayyad Kalkwarf, Kyle J. Holcomb, John B. Damage Control Resuscitation Article Dried plasma provides an alternative for early plasma transfusion in the resuscitation of hemorrhagic shock in environments where fresh frozen plasma is not immediately available. It is produced by freeze-drying or spray-drying liquid or thawed plasma. It is shelf-stable for prolonged periods, can be stored at room temperature, and is easy to transport, reconstitute, and administer. It was widely used in WWII but fell out of favor due to the risk of infectious disease transmission. The German and French experiences with lyophilized plasma are the most extensive and show a good track record of efficacy and safety. Recent studies show many beneficial effects of dried plasma in the treatment of shock in large animal models. Currently, no FDA-licensed product is available in the USA, but several are under development. 2019-05-06 /pmc/articles/PMC7123378/ http://dx.doi.org/10.1007/978-3-030-20820-2_8 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Article Zaza, Mouayyad Kalkwarf, Kyle J. Holcomb, John B. Dried Plasma |
| title | Dried Plasma |
| title_full | Dried Plasma |
| title_fullStr | Dried Plasma |
| title_full_unstemmed | Dried Plasma |
| title_short | Dried Plasma |
| title_sort | dried plasma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123378/ http://dx.doi.org/10.1007/978-3-030-20820-2_8 |
| work_keys_str_mv | AT zazamouayyad driedplasma AT kalkwarfkylej driedplasma AT holcombjohnb driedplasma |