Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)

The analysis on codon usage bias of IFN-a gene of giant panda (Ailuropoda melanoleuca) may provide a basis for understanding the evolution relationship of giant panda and for selecting appropriate host expression systems to improve the expression of target genes. In this paper, the codon usage bias...

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Autores principales: Yi, Yue, Wang, Chengdong, Xu, Zhiwen, Li, Desheng, Zhu, Ling, Li, Fengqin, Qi, Xinqiao, Guo, Wanzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123504/
http://dx.doi.org/10.1007/978-3-642-27537-1_37
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author Yi, Yue
Wang, Chengdong
Xu, Zhiwen
Li, Desheng
Zhu, Ling
Li, Fengqin
Qi, Xinqiao
Guo, Wanzhu
author_facet Yi, Yue
Wang, Chengdong
Xu, Zhiwen
Li, Desheng
Zhu, Ling
Li, Fengqin
Qi, Xinqiao
Guo, Wanzhu
author_sort Yi, Yue
collection PubMed
description The analysis on codon usage bias of IFN-a gene of giant panda (Ailuropoda melanoleuca) may provide a basis for understanding the evolution relationship of giant panda and for selecting appropriate host expression systems to improve the expression of target genes. In this paper, the codon usage bias in the mature IFN-a sequence of giant panda and 15 reference species have been analyzed. The results showed that the synonymous codons with G and C at the third codon position were widely used and the ENC-GC3S plot revealed that the genetic heterogeneity in IFN-a gene was main constrained by mutational bias. Contrastive analysis revealed that there were 40 codons showing distinct usage differences between GpIFN-a and Escherichia coli, 38 codons between GpIFN-a and yeast. and only 30 between GpIFN-a and Homo sapiens. Therefore the Homo expression system may be more suitable for the expression of GpIFN-a genes.
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spelling pubmed-71235042020-04-06 Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca) Yi, Yue Wang, Chengdong Xu, Zhiwen Li, Desheng Zhu, Ling Li, Fengqin Qi, Xinqiao Guo, Wanzhu Information Technology and Agricultural Engineering Article The analysis on codon usage bias of IFN-a gene of giant panda (Ailuropoda melanoleuca) may provide a basis for understanding the evolution relationship of giant panda and for selecting appropriate host expression systems to improve the expression of target genes. In this paper, the codon usage bias in the mature IFN-a sequence of giant panda and 15 reference species have been analyzed. The results showed that the synonymous codons with G and C at the third codon position were widely used and the ENC-GC3S plot revealed that the genetic heterogeneity in IFN-a gene was main constrained by mutational bias. Contrastive analysis revealed that there were 40 codons showing distinct usage differences between GpIFN-a and Escherichia coli, 38 codons between GpIFN-a and yeast. and only 30 between GpIFN-a and Homo sapiens. Therefore the Homo expression system may be more suitable for the expression of GpIFN-a genes. 2012 /pmc/articles/PMC7123504/ http://dx.doi.org/10.1007/978-3-642-27537-1_37 Text en © Springer-Verlag GmbH Berlin Heidelberg 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Yi, Yue
Wang, Chengdong
Xu, Zhiwen
Li, Desheng
Zhu, Ling
Li, Fengqin
Qi, Xinqiao
Guo, Wanzhu
Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title_full Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title_fullStr Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title_full_unstemmed Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title_short Analysis of Codon Usage Bias in Interferon Alpha Gene of the Giant Panda (Ailuropoda Melanoleuca)
title_sort analysis of codon usage bias in interferon alpha gene of the giant panda (ailuropoda melanoleuca)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123504/
http://dx.doi.org/10.1007/978-3-642-27537-1_37
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