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DNA Damaging Drugs
The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by exerting DNA damage. In essence, there are two major response phenotypes available to a cell upon DNA damage, such as a chemotherapeutic drug action, to arrest the cell cycle and repair the damage, to initiate...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123643/ http://dx.doi.org/10.1007/978-3-319-13278-5_2 |
| _version_ | 1783515681603452928 |
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| author | Weber, Georg F. |
| author_facet | Weber, Georg F. |
| author_sort | Weber, Georg F. |
| collection | PubMed |
| description | The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by exerting DNA damage. In essence, there are two major response phenotypes available to a cell upon DNA damage, such as a chemotherapeutic drug action, to arrest the cell cycle and repair the damage, to initiate a pathway to apoptosis (programmed cell death). |
| format | Online Article Text |
| id | pubmed-7123643 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71236432020-04-06 DNA Damaging Drugs Weber, Georg F. Molecular Therapies of Cancer Article The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by exerting DNA damage. In essence, there are two major response phenotypes available to a cell upon DNA damage, such as a chemotherapeutic drug action, to arrest the cell cycle and repair the damage, to initiate a pathway to apoptosis (programmed cell death). 2014-12-08 /pmc/articles/PMC7123643/ http://dx.doi.org/10.1007/978-3-319-13278-5_2 Text en © Springer International Publishing Switzerland 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Article Weber, Georg F. DNA Damaging Drugs |
| title | DNA Damaging Drugs |
| title_full | DNA Damaging Drugs |
| title_fullStr | DNA Damaging Drugs |
| title_full_unstemmed | DNA Damaging Drugs |
| title_short | DNA Damaging Drugs |
| title_sort | dna damaging drugs |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123643/ http://dx.doi.org/10.1007/978-3-319-13278-5_2 |
| work_keys_str_mv | AT webergeorgf dnadamagingdrugs |