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Gastrointestinal Infections
Establishing a specific etiology for gastrointestinal infections can be challenging because of the common clinical features and wide variety of causative microorganisms. In many cases, the etiologic agent cannot be determined using traditional diagnostic methods and may result in unnecessary antibio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123654/ http://dx.doi.org/10.1007/978-3-319-19674-9_50 |
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author | Burd, Eileen M. Hinrichs, Benjamin H. |
author_facet | Burd, Eileen M. Hinrichs, Benjamin H. |
author_sort | Burd, Eileen M. |
collection | PubMed |
description | Establishing a specific etiology for gastrointestinal infections can be challenging because of the common clinical features and wide variety of causative microorganisms. In many cases, the etiologic agent cannot be determined using traditional diagnostic methods and may result in unnecessary antibiotic use or prolonged periods of illness. Molecular tests provide many advantages over traditional laboratory methods but, with the exception of a few analytes, are still largely in the developmental phase for gastrointestinal pathogens and are not widely used. The main advantages of molecular tests include increased sensitivity and the ability to detect agents which will not grow in culture. To test for all possible gastrointestinal pathogens at one time would require a large panel that would include a variety of bacterial, viral and parasitic agents. Challenges inherent in developing diagnostic molecular panels include ensuring that all variants of a particular microorganism can be detected as well as the rapid evolution of pathogens. In this chapter, the diagnostic merit of molecular tests as well as available tests will be presented for the major groups of gastrointestinal pathogens. |
format | Online Article Text |
id | pubmed-7123654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71236542020-04-06 Gastrointestinal Infections Burd, Eileen M. Hinrichs, Benjamin H. Molecular Pathology in Clinical Practice Article Establishing a specific etiology for gastrointestinal infections can be challenging because of the common clinical features and wide variety of causative microorganisms. In many cases, the etiologic agent cannot be determined using traditional diagnostic methods and may result in unnecessary antibiotic use or prolonged periods of illness. Molecular tests provide many advantages over traditional laboratory methods but, with the exception of a few analytes, are still largely in the developmental phase for gastrointestinal pathogens and are not widely used. The main advantages of molecular tests include increased sensitivity and the ability to detect agents which will not grow in culture. To test for all possible gastrointestinal pathogens at one time would require a large panel that would include a variety of bacterial, viral and parasitic agents. Challenges inherent in developing diagnostic molecular panels include ensuring that all variants of a particular microorganism can be detected as well as the rapid evolution of pathogens. In this chapter, the diagnostic merit of molecular tests as well as available tests will be presented for the major groups of gastrointestinal pathogens. 2015-05-19 /pmc/articles/PMC7123654/ http://dx.doi.org/10.1007/978-3-319-19674-9_50 Text en © Springer International Publishing Switzerland 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Burd, Eileen M. Hinrichs, Benjamin H. Gastrointestinal Infections |
title | Gastrointestinal Infections |
title_full | Gastrointestinal Infections |
title_fullStr | Gastrointestinal Infections |
title_full_unstemmed | Gastrointestinal Infections |
title_short | Gastrointestinal Infections |
title_sort | gastrointestinal infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123654/ http://dx.doi.org/10.1007/978-3-319-19674-9_50 |
work_keys_str_mv | AT burdeileenm gastrointestinalinfections AT hinrichsbenjaminh gastrointestinalinfections |