Introduction

Writing case reports can provide many scholarly, clinical, and academic benefits. The inspiration for case reports can arise in unexpected places. Unlike randomized trials, which confirm and quantify the evidence, case reports provide inspiration, new ideas, and fresh hypotheses. When randomized trials are lacking, case reports may become the best available evidence for clinical decision-making. Case reports also function as “reports from the front line” with timely and critical information on emerging diseases, such as Zika and Ebola viruses. In the twenty first century, case reports have evolved new forms and functions that parallel the rapid growth of biometrics and computer technology. Today’s medical students and early-career physicians will help to determine the future of the case report.