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Pathogenesis of Kingella kingae Disease
The pathogenesis of Kingella kingae disease begins with colonization of the oropharynx, a process facilitated by type IV pili and a non-pilus trimeric autotransporter adhesin called Knh, factors that mediate adherence to respiratory epithelial cells. A potent RTX cytotoxin with broad cellular specif...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123807/ http://dx.doi.org/10.1007/978-3-319-43729-3_3 |
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author | Porsch, Eric A. Rempe, Katherine A. |
author_facet | Porsch, Eric A. Rempe, Katherine A. |
author_sort | Porsch, Eric A. |
collection | PubMed |
description | The pathogenesis of Kingella kingae disease begins with colonization of the oropharynx, a process facilitated by type IV pili and a non-pilus trimeric autotransporter adhesin called Knh, factors that mediate adherence to respiratory epithelial cells. A potent RTX cytotoxin with broad cellular specificity may play a role in disrupting the epithelial barrier and facilitating invasion of the bloodstream, possibly in concert with a viral coinfection. Once in the bloodstream, the organism can disseminate to sites of invasive disease, primarily the joints, bones, and endocardium. Survival in the bloodstream and dissemination are likely aided by expression of a capsular polysaccharide and an exopolysaccharide galactan. The evidence for antigenic diversity of K. kingae surface exposed protein epitopes and the observation that type IV pili are selected against during invasive disease suggest that immune system pressure plays an important role in K. kingae pathogenicity. |
format | Online Article Text |
id | pubmed-7123807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71238072020-04-06 Pathogenesis of Kingella kingae Disease Porsch, Eric A. Rempe, Katherine A. Advances in Understanding Kingella kingae Article The pathogenesis of Kingella kingae disease begins with colonization of the oropharynx, a process facilitated by type IV pili and a non-pilus trimeric autotransporter adhesin called Knh, factors that mediate adherence to respiratory epithelial cells. A potent RTX cytotoxin with broad cellular specificity may play a role in disrupting the epithelial barrier and facilitating invasion of the bloodstream, possibly in concert with a viral coinfection. Once in the bloodstream, the organism can disseminate to sites of invasive disease, primarily the joints, bones, and endocardium. Survival in the bloodstream and dissemination are likely aided by expression of a capsular polysaccharide and an exopolysaccharide galactan. The evidence for antigenic diversity of K. kingae surface exposed protein epitopes and the observation that type IV pili are selected against during invasive disease suggest that immune system pressure plays an important role in K. kingae pathogenicity. 2016-08-27 /pmc/articles/PMC7123807/ http://dx.doi.org/10.1007/978-3-319-43729-3_3 Text en © The Author(s) 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Porsch, Eric A. Rempe, Katherine A. Pathogenesis of Kingella kingae Disease |
title | Pathogenesis of Kingella kingae Disease |
title_full | Pathogenesis of Kingella kingae Disease |
title_fullStr | Pathogenesis of Kingella kingae Disease |
title_full_unstemmed | Pathogenesis of Kingella kingae Disease |
title_short | Pathogenesis of Kingella kingae Disease |
title_sort | pathogenesis of kingella kingae disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123807/ http://dx.doi.org/10.1007/978-3-319-43729-3_3 |
work_keys_str_mv | AT porscherica pathogenesisofkingellakingaedisease AT rempekatherinea pathogenesisofkingellakingaedisease |