Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children

It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeat...

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Detalles Bibliográficos
Autores principales: Semenov, Boris, Zverev, Vitaly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123936/
https://www.ncbi.nlm.nih.gov/pubmed/17713026
http://dx.doi.org/10.1007/978-0-387-72005-0_40
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author Semenov, Boris
Zverev, Vitaly
author_facet Semenov, Boris
Zverev, Vitaly
author_sort Semenov, Boris
collection PubMed
description It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.
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spelling pubmed-71239362020-04-06 Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children Semenov, Boris Zverev, Vitaly Immune-Mediated Diseases Article It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age. 2007 /pmc/articles/PMC7123936/ /pubmed/17713026 http://dx.doi.org/10.1007/978-0-387-72005-0_40 Text en © Springer Science+Business Media, LLC 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Semenov, Boris
Zverev, Vitaly
Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title_full Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title_fullStr Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title_full_unstemmed Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title_short Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children
title_sort vaccine containing natural tlr ligands protects from salmonella typhimurium infection in mice and acute respiratory infections in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123936/
https://www.ncbi.nlm.nih.gov/pubmed/17713026
http://dx.doi.org/10.1007/978-0-387-72005-0_40
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