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Fibrinogen α-Chain as a Serum Marker of Liver Disease

Liver fibrosis is the hepatic response to an insult characterized by an accumulation of extracellular matrix proteins. If the underlying cause is not treated or eliminated, the disease can progress and may lead to several clinical complications including hepatocellular carcinoma or even death. Thus,...

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Detalles Bibliográficos
Autores principales: Marfà, Santiago, Jimenez, Wladimiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123997/
http://dx.doi.org/10.1007/978-94-007-7675-3_7
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author Marfà, Santiago
Jimenez, Wladimiro
author_facet Marfà, Santiago
Jimenez, Wladimiro
author_sort Marfà, Santiago
collection PubMed
description Liver fibrosis is the hepatic response to an insult characterized by an accumulation of extracellular matrix proteins. If the underlying cause is not treated or eliminated, the disease can progress and may lead to several clinical complications including hepatocellular carcinoma or even death. Thus, detection, staging, and follow-up of liver fibrosis are the main issues in the prognosis and treatment of patients with chronic liver disease. In recent years, new advances in mass spectrometry-based proteomics technology and protein fractionation techniques have improved protein identification as well as protein quantification in many different samples and diseases including liver fibrosis. In particular, the fibrinogen α chain and more specifically the serum levels of the 5.9 kDa fragment of fibrinogen α C-chain have shown to be altered in several hepatic etiologies. In fact, these results have been reproduced by different laboratories, and recently a marked downregulation of this protein fragment has also been described in the initial stages of liver fibrosis. In this chapter, we have described the potential role of fibrinogen α chain and particularly the 5.9 kDa fragment of fibrinogen α C-chain as a circulating marker of liver fibrosis.
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spelling pubmed-71239972020-04-06 Fibrinogen α-Chain as a Serum Marker of Liver Disease Marfà, Santiago Jimenez, Wladimiro Biomarkers in Liver Disease Article Liver fibrosis is the hepatic response to an insult characterized by an accumulation of extracellular matrix proteins. If the underlying cause is not treated or eliminated, the disease can progress and may lead to several clinical complications including hepatocellular carcinoma or even death. Thus, detection, staging, and follow-up of liver fibrosis are the main issues in the prognosis and treatment of patients with chronic liver disease. In recent years, new advances in mass spectrometry-based proteomics technology and protein fractionation techniques have improved protein identification as well as protein quantification in many different samples and diseases including liver fibrosis. In particular, the fibrinogen α chain and more specifically the serum levels of the 5.9 kDa fragment of fibrinogen α C-chain have shown to be altered in several hepatic etiologies. In fact, these results have been reproduced by different laboratories, and recently a marked downregulation of this protein fragment has also been described in the initial stages of liver fibrosis. In this chapter, we have described the potential role of fibrinogen α chain and particularly the 5.9 kDa fragment of fibrinogen α C-chain as a circulating marker of liver fibrosis. 2016-12-05 /pmc/articles/PMC7123997/ http://dx.doi.org/10.1007/978-94-007-7675-3_7 Text en © Springer Science+Business Media Dordrecht 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Marfà, Santiago
Jimenez, Wladimiro
Fibrinogen α-Chain as a Serum Marker of Liver Disease
title Fibrinogen α-Chain as a Serum Marker of Liver Disease
title_full Fibrinogen α-Chain as a Serum Marker of Liver Disease
title_fullStr Fibrinogen α-Chain as a Serum Marker of Liver Disease
title_full_unstemmed Fibrinogen α-Chain as a Serum Marker of Liver Disease
title_short Fibrinogen α-Chain as a Serum Marker of Liver Disease
title_sort fibrinogen α-chain as a serum marker of liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123997/
http://dx.doi.org/10.1007/978-94-007-7675-3_7
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