Modeling the Case of Early Detection of Ebola Virus Disease

The most recent Ebola outbreak in West Africa highlighted critical weaknesses in the medical infrastructure of the affected countries, including effective diagnostics tools, sufficient isolation wards, and enough medical personnel. Here, we develop and analyze a mathematical model to assess the impa...

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Detalles Bibliográficos
Autores principales: Chowell, Diego, Safan, Muntaser, Castillo-Chavez, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124031/
http://dx.doi.org/10.1007/978-3-319-40413-4_5
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author Chowell, Diego
Safan, Muntaser
Castillo-Chavez, Carlos
author_facet Chowell, Diego
Safan, Muntaser
Castillo-Chavez, Carlos
author_sort Chowell, Diego
collection PubMed
description The most recent Ebola outbreak in West Africa highlighted critical weaknesses in the medical infrastructure of the affected countries, including effective diagnostics tools, sufficient isolation wards, and enough medical personnel. Here, we develop and analyze a mathematical model to assess the impact of early diagnosis of pre-symptomatic individuals on the transmission dynamics of Ebola virus disease in West Africa. Our findings highlight the importance of implementing integrated control measures of early diagnosis and isolation. The mathematical analysis shows a threshold where early diagnosis of pre-symptomatic individuals, combined with a sufficient level of effective isolation, can lead to an epidemic control of Ebola virus disease.
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spelling pubmed-71240312020-04-06 Modeling the Case of Early Detection of Ebola Virus Disease Chowell, Diego Safan, Muntaser Castillo-Chavez, Carlos Mathematical and Statistical Modeling for Emerging and Re-emerging Infectious Diseases Article The most recent Ebola outbreak in West Africa highlighted critical weaknesses in the medical infrastructure of the affected countries, including effective diagnostics tools, sufficient isolation wards, and enough medical personnel. Here, we develop and analyze a mathematical model to assess the impact of early diagnosis of pre-symptomatic individuals on the transmission dynamics of Ebola virus disease in West Africa. Our findings highlight the importance of implementing integrated control measures of early diagnosis and isolation. The mathematical analysis shows a threshold where early diagnosis of pre-symptomatic individuals, combined with a sufficient level of effective isolation, can lead to an epidemic control of Ebola virus disease. 2016-07-28 /pmc/articles/PMC7124031/ http://dx.doi.org/10.1007/978-3-319-40413-4_5 Text en © Springer International Publishing Switzerland 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Chowell, Diego
Safan, Muntaser
Castillo-Chavez, Carlos
Modeling the Case of Early Detection of Ebola Virus Disease
title Modeling the Case of Early Detection of Ebola Virus Disease
title_full Modeling the Case of Early Detection of Ebola Virus Disease
title_fullStr Modeling the Case of Early Detection of Ebola Virus Disease
title_full_unstemmed Modeling the Case of Early Detection of Ebola Virus Disease
title_short Modeling the Case of Early Detection of Ebola Virus Disease
title_sort modeling the case of early detection of ebola virus disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124031/
http://dx.doi.org/10.1007/978-3-319-40413-4_5
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