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Influence of Gender on Outcome of Severe Sepsis

Whether gender influences the outcome of severe sepsis remains a matter of debate. Because many confounding variables may affect observed associations between gender and mortality, high-quality statistical analyses are essential to carefully adjust the two groups of patients. About 55% to 65% of pat...

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Detalles Bibliográficos
Autores principales: Adrie, C., Azoulay, E., Timsit, J. -F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124082/
http://dx.doi.org/10.1007/978-3-540-49433-1_80
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author Adrie, C.
Azoulay, E.
Timsit, J. -F.
author_facet Adrie, C.
Azoulay, E.
Timsit, J. -F.
author_sort Adrie, C.
collection PubMed
description Whether gender influences the outcome of severe sepsis remains a matter of debate. Because many confounding variables may affect observed associations between gender and mortality, high-quality statistical analyses are essential to carefully adjust the two groups of patients. About 55% to 65% of patients with sepsis have chronic co-morbidities associated with immune dysfunction (e.g., chronic renal failure, diabetes mellitus, human immunodeficiency virus [HIV] infection, and alcohol abuse), which increase the susceptibility to sepsis [1]. Genetic polymorphisms that affect the susceptibility to infection and/or the severity of the systemic response to infection [2] may lead to variability among individuals and between males and females [3]. Access to healthcare, another determinant of the incidence and outcome of sepsis, varies according to age, ethnic group, and gender, although a recent study conducted in the USA found only relatively small quality-of-care differences between males and females or across income groups compared to the gap for each subgroup between observed and desirable quality of health care [4]. Here, we review the data on the existence of, and reasons for, associations between gender and outcome of severe sepsis (Fig. 1).
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spelling pubmed-71240822020-04-06 Influence of Gender on Outcome of Severe Sepsis Adrie, C. Azoulay, E. Timsit, J. -F. Intensive Care Medicine Article Whether gender influences the outcome of severe sepsis remains a matter of debate. Because many confounding variables may affect observed associations between gender and mortality, high-quality statistical analyses are essential to carefully adjust the two groups of patients. About 55% to 65% of patients with sepsis have chronic co-morbidities associated with immune dysfunction (e.g., chronic renal failure, diabetes mellitus, human immunodeficiency virus [HIV] infection, and alcohol abuse), which increase the susceptibility to sepsis [1]. Genetic polymorphisms that affect the susceptibility to infection and/or the severity of the systemic response to infection [2] may lead to variability among individuals and between males and females [3]. Access to healthcare, another determinant of the incidence and outcome of sepsis, varies according to age, ethnic group, and gender, although a recent study conducted in the USA found only relatively small quality-of-care differences between males and females or across income groups compared to the gap for each subgroup between observed and desirable quality of health care [4]. Here, we review the data on the existence of, and reasons for, associations between gender and outcome of severe sepsis (Fig. 1). 2007 /pmc/articles/PMC7124082/ http://dx.doi.org/10.1007/978-3-540-49433-1_80 Text en © Springer Science + Business Media Inc. 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Adrie, C.
Azoulay, E.
Timsit, J. -F.
Influence of Gender on Outcome of Severe Sepsis
title Influence of Gender on Outcome of Severe Sepsis
title_full Influence of Gender on Outcome of Severe Sepsis
title_fullStr Influence of Gender on Outcome of Severe Sepsis
title_full_unstemmed Influence of Gender on Outcome of Severe Sepsis
title_short Influence of Gender on Outcome of Severe Sepsis
title_sort influence of gender on outcome of severe sepsis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124082/
http://dx.doi.org/10.1007/978-3-540-49433-1_80
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