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Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression

A robust biomarker screening and validation is crucial for overcoming the current limits in the clinical management of infectious diseases. In this chapter, a general workflow for metabolomics is summarized. Subsequently, an overview of the major contributions of this omics science to the field of b...

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Autores principales: Fernández-García, Miguel, Rojo, David, Rey-Stolle, Fernanda, García, Antonia, Barbas, Coral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124096/
https://www.ncbi.nlm.nih.gov/pubmed/30535603
http://dx.doi.org/10.1007/978-3-319-74932-7_7
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author Fernández-García, Miguel
Rojo, David
Rey-Stolle, Fernanda
García, Antonia
Barbas, Coral
author_facet Fernández-García, Miguel
Rojo, David
Rey-Stolle, Fernanda
García, Antonia
Barbas, Coral
author_sort Fernández-García, Miguel
collection PubMed
description A robust biomarker screening and validation is crucial for overcoming the current limits in the clinical management of infectious diseases. In this chapter, a general workflow for metabolomics is summarized. Subsequently, an overview of the major contributions of this omics science to the field of biomarkers of infectious diseases is discussed. Different approaches using a variety of analytical platforms can be distinguished to unveil the key metabolites for the diagnosis, prognosis, response to treatment and susceptibility for infectious diseases. To allow the implementation of such biomarkers into the clinics, the performance of large-scale studies employing solid validation criteria becomes essential. Focusing on the etiological agents and after an extensive review of the field, we present a comprehensive revision of the main metabolic biomarkers of viral, bacterial, fungal, and parasitic diseases. Finally, we discussed several articles which show the strongest validation criteria. Following these research avenues, precious clinical resources will be revealed, allowing for reduced misdiagnosis, more efficient therapies, and affordable costs, ultimately leading to a better patient management.
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spelling pubmed-71240962020-04-06 Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression Fernández-García, Miguel Rojo, David Rey-Stolle, Fernanda García, Antonia Barbas, Coral Metabolic Interaction in Infection Article A robust biomarker screening and validation is crucial for overcoming the current limits in the clinical management of infectious diseases. In this chapter, a general workflow for metabolomics is summarized. Subsequently, an overview of the major contributions of this omics science to the field of biomarkers of infectious diseases is discussed. Different approaches using a variety of analytical platforms can be distinguished to unveil the key metabolites for the diagnosis, prognosis, response to treatment and susceptibility for infectious diseases. To allow the implementation of such biomarkers into the clinics, the performance of large-scale studies employing solid validation criteria becomes essential. Focusing on the etiological agents and after an extensive review of the field, we present a comprehensive revision of the main metabolic biomarkers of viral, bacterial, fungal, and parasitic diseases. Finally, we discussed several articles which show the strongest validation criteria. Following these research avenues, precious clinical resources will be revealed, allowing for reduced misdiagnosis, more efficient therapies, and affordable costs, ultimately leading to a better patient management. 2018-01-02 /pmc/articles/PMC7124096/ /pubmed/30535603 http://dx.doi.org/10.1007/978-3-319-74932-7_7 Text en © Springer International Publishing AG, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Fernández-García, Miguel
Rojo, David
Rey-Stolle, Fernanda
García, Antonia
Barbas, Coral
Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title_full Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title_fullStr Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title_full_unstemmed Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title_short Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression
title_sort metabolomic-based methods in diagnosis and monitoring infection progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124096/
https://www.ncbi.nlm.nih.gov/pubmed/30535603
http://dx.doi.org/10.1007/978-3-319-74932-7_7
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