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Virus-Like Particles as a Vaccine Delivery System: Myths and Facts
Vaccines against viral disease have traditionally relied on attenuated virus strains or inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in heterologous systems have been effective for some pathogens, but have often suffered from poor immunogenicity due to incorre...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124136/ https://www.ncbi.nlm.nih.gov/pubmed/20047040 http://dx.doi.org/10.1007/978-1-4419-1132-2_11 |
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author | Roy, Polly Noad, Rob |
author_facet | Roy, Polly Noad, Rob |
author_sort | Roy, Polly |
collection | PubMed |
description | Vaccines against viral disease have traditionally relied on attenuated virus strains or inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in heterologous systems have been effective for some pathogens, but have often suffered from poor immunogenicity due to incorrect protein folding or modification. In this chapter we focus on a specific class of viral subunit vaccine that mimics the overall structure of virus particles and thus preserves the native antigenic conformation of the immunogenic proteins. These virus-like particles (VLPs) have been produced for a wide range of taxonomically and structurally distinct viruses, and have unique advantages in terms of safety and immunogenicity over previous approaches. With new VLP vaccines for papillomavirus beginning to reach the market place we argue that this technology has now ‘come-of-age’ and must be considered a viable vaccine strategy. |
format | Online Article Text |
id | pubmed-7124136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71241362020-04-06 Virus-Like Particles as a Vaccine Delivery System: Myths and Facts Roy, Polly Noad, Rob Pharmaceutical Biotechnology Article Vaccines against viral disease have traditionally relied on attenuated virus strains or inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in heterologous systems have been effective for some pathogens, but have often suffered from poor immunogenicity due to incorrect protein folding or modification. In this chapter we focus on a specific class of viral subunit vaccine that mimics the overall structure of virus particles and thus preserves the native antigenic conformation of the immunogenic proteins. These virus-like particles (VLPs) have been produced for a wide range of taxonomically and structurally distinct viruses, and have unique advantages in terms of safety and immunogenicity over previous approaches. With new VLP vaccines for papillomavirus beginning to reach the market place we argue that this technology has now ‘come-of-age’ and must be considered a viable vaccine strategy. 2009-12-30 /pmc/articles/PMC7124136/ /pubmed/20047040 http://dx.doi.org/10.1007/978-1-4419-1132-2_11 Text en © Landes Bioscience and Springer Science+Business Media 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Roy, Polly Noad, Rob Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title | Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title_full | Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title_fullStr | Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title_full_unstemmed | Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title_short | Virus-Like Particles as a Vaccine Delivery System: Myths and Facts |
title_sort | virus-like particles as a vaccine delivery system: myths and facts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124136/ https://www.ncbi.nlm.nih.gov/pubmed/20047040 http://dx.doi.org/10.1007/978-1-4419-1132-2_11 |
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