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Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients

Increased concentrations of soluble HLA class I and class II molecules (sHLA-I and sHLA-II) have been observed in infectious, inflammatory, and autoimmune diseases. Because autoimmune mechanisms are considered to play a role in the pathogenesis of multiple sclerosis (MS), we decided to dose sHLA-I a...

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Autores principales: Filaci, Gilberto, Contini, Paola, Brenci, Sabrina, Gazzola, Paola, Lanza, Lorella, Scudeletti, Marco, Indiveri, Francesco, Mancardi, Giovanni Luigi, Puppo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc. 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124268/
https://www.ncbi.nlm.nih.gov/pubmed/9154458
http://dx.doi.org/10.1016/S0198-8859(97)00004-9
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author Filaci, Gilberto
Contini, Paola
Brenci, Sabrina
Gazzola, Paola
Lanza, Lorella
Scudeletti, Marco
Indiveri, Francesco
Mancardi, Giovanni Luigi
Puppo, Francesco
author_facet Filaci, Gilberto
Contini, Paola
Brenci, Sabrina
Gazzola, Paola
Lanza, Lorella
Scudeletti, Marco
Indiveri, Francesco
Mancardi, Giovanni Luigi
Puppo, Francesco
author_sort Filaci, Gilberto
collection PubMed
description Increased concentrations of soluble HLA class I and class II molecules (sHLA-I and sHLA-II) have been observed in infectious, inflammatory, and autoimmune diseases. Because autoimmune mechanisms are considered to play a role in the pathogenesis of multiple sclerosis (MS), we decided to dose sHLA-I and sHLA-II in serum and cerebrospinal fluid (CSF) of MS patients comparing their concentrations with those observed in serum and CSF of patients with other neurologic diseases (OND) without evidence of neuroradiologic involvement of central nervous system (CNS) and in serum of healthy donors. The serum concentrations of sHLA-I were higher in both MS and OND patients than in healthy donors (P < 0.05) whereas sHLA-II serum concentrations were lower in MS patients than in both OND patients and healthy donors (P < 0.01). Detectable amounts of sHLA-II were observed in the CSF of 45% of MS patients and in CSF of only 6% of OND patients (P < 0.001). In MS patients a significant correlation between sHLA-I serum and CSF concentrations was observed (P < 0.01), whereas sHLA-II serum and CSF levels did not correlate. In conclusion, alterations of sHLA-I and sHLA-II serum and CSF concentrations are present in MS patients and could be involved in the induction of enhanced susceptibility to develop MS or in MS pathogenesis.
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spelling pubmed-71242682020-04-08 Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients Filaci, Gilberto Contini, Paola Brenci, Sabrina Gazzola, Paola Lanza, Lorella Scudeletti, Marco Indiveri, Francesco Mancardi, Giovanni Luigi Puppo, Francesco Hum Immunol Original Articles Increased concentrations of soluble HLA class I and class II molecules (sHLA-I and sHLA-II) have been observed in infectious, inflammatory, and autoimmune diseases. Because autoimmune mechanisms are considered to play a role in the pathogenesis of multiple sclerosis (MS), we decided to dose sHLA-I and sHLA-II in serum and cerebrospinal fluid (CSF) of MS patients comparing their concentrations with those observed in serum and CSF of patients with other neurologic diseases (OND) without evidence of neuroradiologic involvement of central nervous system (CNS) and in serum of healthy donors. The serum concentrations of sHLA-I were higher in both MS and OND patients than in healthy donors (P < 0.05) whereas sHLA-II serum concentrations were lower in MS patients than in both OND patients and healthy donors (P < 0.01). Detectable amounts of sHLA-II were observed in the CSF of 45% of MS patients and in CSF of only 6% of OND patients (P < 0.001). In MS patients a significant correlation between sHLA-I serum and CSF concentrations was observed (P < 0.01), whereas sHLA-II serum and CSF levels did not correlate. In conclusion, alterations of sHLA-I and sHLA-II serum and CSF concentrations are present in MS patients and could be involved in the induction of enhanced susceptibility to develop MS or in MS pathogenesis. Elsevier Science Inc. 1997-04-15 1998-11-10 /pmc/articles/PMC7124268/ /pubmed/9154458 http://dx.doi.org/10.1016/S0198-8859(97)00004-9 Text en Copyright © 1997 Elsevier Science Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Articles
Filaci, Gilberto
Contini, Paola
Brenci, Sabrina
Gazzola, Paola
Lanza, Lorella
Scudeletti, Marco
Indiveri, Francesco
Mancardi, Giovanni Luigi
Puppo, Francesco
Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title_full Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title_fullStr Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title_full_unstemmed Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title_short Soluble HLA Class I and Class II Molecule Levels in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients
title_sort soluble hla class i and class ii molecule levels in serum and cerebrospinal fluid of multiple sclerosis patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124268/
https://www.ncbi.nlm.nih.gov/pubmed/9154458
http://dx.doi.org/10.1016/S0198-8859(97)00004-9
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