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Genome elimination mediated by gene expression from a selfish chromosome
Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124933/ https://www.ncbi.nlm.nih.gov/pubmed/32284986 http://dx.doi.org/10.1126/sciadv.aaz9808 |
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author | Dalla Benetta, Elena Antoshechkin, Igor Yang, Ting Nguyen, Hoa Quang My Ferree, Patrick M. Akbari, Omar S. |
author_facet | Dalla Benetta, Elena Antoshechkin, Igor Yang, Ting Nguyen, Hoa Quang My Ferree, Patrick M. Akbari, Omar S. |
author_sort | Dalla Benetta, Elena |
collection | PubMed |
description | Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp Nasonia vitripennis. PSR causes female-to-male conversion by destroying the sperm’s hereditary material in young embryos to drive. Using RNA interference, we demonstrate that testis-specific expression of a PSR-linked gene, named haploidizer, facilitates this genome elimination–and–sex conversion effect. haploidizer encodes a putative protein with a DNA binding domain, suggesting a functional link with the sperm-derived chromatin. |
format | Online Article Text |
id | pubmed-7124933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-71249332020-04-13 Genome elimination mediated by gene expression from a selfish chromosome Dalla Benetta, Elena Antoshechkin, Igor Yang, Ting Nguyen, Hoa Quang My Ferree, Patrick M. Akbari, Omar S. Sci Adv Research Articles Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp Nasonia vitripennis. PSR causes female-to-male conversion by destroying the sperm’s hereditary material in young embryos to drive. Using RNA interference, we demonstrate that testis-specific expression of a PSR-linked gene, named haploidizer, facilitates this genome elimination–and–sex conversion effect. haploidizer encodes a putative protein with a DNA binding domain, suggesting a functional link with the sperm-derived chromatin. American Association for the Advancement of Science 2020-04-03 /pmc/articles/PMC7124933/ /pubmed/32284986 http://dx.doi.org/10.1126/sciadv.aaz9808 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Dalla Benetta, Elena Antoshechkin, Igor Yang, Ting Nguyen, Hoa Quang My Ferree, Patrick M. Akbari, Omar S. Genome elimination mediated by gene expression from a selfish chromosome |
title | Genome elimination mediated by gene expression from a selfish chromosome |
title_full | Genome elimination mediated by gene expression from a selfish chromosome |
title_fullStr | Genome elimination mediated by gene expression from a selfish chromosome |
title_full_unstemmed | Genome elimination mediated by gene expression from a selfish chromosome |
title_short | Genome elimination mediated by gene expression from a selfish chromosome |
title_sort | genome elimination mediated by gene expression from a selfish chromosome |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124933/ https://www.ncbi.nlm.nih.gov/pubmed/32284986 http://dx.doi.org/10.1126/sciadv.aaz9808 |
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