Cargando…

Genome elimination mediated by gene expression from a selfish chromosome

Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequen...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalla Benetta, Elena, Antoshechkin, Igor, Yang, Ting, Nguyen, Hoa Quang My, Ferree, Patrick M., Akbari, Omar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124933/
https://www.ncbi.nlm.nih.gov/pubmed/32284986
http://dx.doi.org/10.1126/sciadv.aaz9808
_version_ 1783515856400023552
author Dalla Benetta, Elena
Antoshechkin, Igor
Yang, Ting
Nguyen, Hoa Quang My
Ferree, Patrick M.
Akbari, Omar S.
author_facet Dalla Benetta, Elena
Antoshechkin, Igor
Yang, Ting
Nguyen, Hoa Quang My
Ferree, Patrick M.
Akbari, Omar S.
author_sort Dalla Benetta, Elena
collection PubMed
description Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp Nasonia vitripennis. PSR causes female-to-male conversion by destroying the sperm’s hereditary material in young embryos to drive. Using RNA interference, we demonstrate that testis-specific expression of a PSR-linked gene, named haploidizer, facilitates this genome elimination–and–sex conversion effect. haploidizer encodes a putative protein with a DNA binding domain, suggesting a functional link with the sperm-derived chromatin.
format Online
Article
Text
id pubmed-7124933
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-71249332020-04-13 Genome elimination mediated by gene expression from a selfish chromosome Dalla Benetta, Elena Antoshechkin, Igor Yang, Ting Nguyen, Hoa Quang My Ferree, Patrick M. Akbari, Omar S. Sci Adv Research Articles Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp Nasonia vitripennis. PSR causes female-to-male conversion by destroying the sperm’s hereditary material in young embryos to drive. Using RNA interference, we demonstrate that testis-specific expression of a PSR-linked gene, named haploidizer, facilitates this genome elimination–and–sex conversion effect. haploidizer encodes a putative protein with a DNA binding domain, suggesting a functional link with the sperm-derived chromatin. American Association for the Advancement of Science 2020-04-03 /pmc/articles/PMC7124933/ /pubmed/32284986 http://dx.doi.org/10.1126/sciadv.aaz9808 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Dalla Benetta, Elena
Antoshechkin, Igor
Yang, Ting
Nguyen, Hoa Quang My
Ferree, Patrick M.
Akbari, Omar S.
Genome elimination mediated by gene expression from a selfish chromosome
title Genome elimination mediated by gene expression from a selfish chromosome
title_full Genome elimination mediated by gene expression from a selfish chromosome
title_fullStr Genome elimination mediated by gene expression from a selfish chromosome
title_full_unstemmed Genome elimination mediated by gene expression from a selfish chromosome
title_short Genome elimination mediated by gene expression from a selfish chromosome
title_sort genome elimination mediated by gene expression from a selfish chromosome
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124933/
https://www.ncbi.nlm.nih.gov/pubmed/32284986
http://dx.doi.org/10.1126/sciadv.aaz9808
work_keys_str_mv AT dallabenettaelena genomeeliminationmediatedbygeneexpressionfromaselfishchromosome
AT antoshechkinigor genomeeliminationmediatedbygeneexpressionfromaselfishchromosome
AT yangting genomeeliminationmediatedbygeneexpressionfromaselfishchromosome
AT nguyenhoaquangmy genomeeliminationmediatedbygeneexpressionfromaselfishchromosome
AT ferreepatrickm genomeeliminationmediatedbygeneexpressionfromaselfishchromosome
AT akbariomars genomeeliminationmediatedbygeneexpressionfromaselfishchromosome