Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme

Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its application to a model RNA: the core glmS rib...

Descripción completa

Detalles Bibliográficos
Autores principales: Andreasson, Johan O. L., Savinov, Andrew, Block, Steven M., Greenleaf, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125110/
https://www.ncbi.nlm.nih.gov/pubmed/32245964
http://dx.doi.org/10.1038/s41467-020-15540-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125110/
https://www.ncbi.nlm.nih.gov/pubmed/32245964
http://dx.doi.org/10.1038/s41467-020-15540-1

Ejemplares similares