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Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its application to a model RNA: the core glmS rib...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125110/ https://www.ncbi.nlm.nih.gov/pubmed/32245964 http://dx.doi.org/10.1038/s41467-020-15540-1 |