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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism

Prokaryotic Na(V) channels are tetramers and eukaryotic Na(V) channels consist of a single subunit containing four domains. Each monomer/domain contains six transmembrane segments (S1-S6), S1-S4 being the voltage-sensor domain and S5-S6 the pore domain. A crystal structure of Na(V)Ms, a prokaryotic...

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Detalles Bibliográficos
Autores principales:	Malak, Olfat A., Abderemane-Ali, Fayal, Wei, Yue, Coyan, Fabien C., Pontus, Gilyane, Shaya, David, Marionneau, Céline, Loussouarn, Gildas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125111/ https://www.ncbi.nlm.nih.gov/pubmed/32246066 http://dx.doi.org/10.1038/s41598-020-62615-6

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