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Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial eff...

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Autores principales: Kobayashi, Yuki, Imamura, Ryoichi, Koyama, Yoshihisa, Kondo, Makoto, Kobayashi, Hikaru, Nonomura, Norio, Shimada, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125117/
https://www.ncbi.nlm.nih.gov/pubmed/32246095
http://dx.doi.org/10.1038/s41598-020-62755-9
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author Kobayashi, Yuki
Imamura, Ryoichi
Koyama, Yoshihisa
Kondo, Makoto
Kobayashi, Hikaru
Nonomura, Norio
Shimada, Shoichi
author_facet Kobayashi, Yuki
Imamura, Ryoichi
Koyama, Yoshihisa
Kondo, Makoto
Kobayashi, Hikaru
Nonomura, Norio
Shimada, Shoichi
author_sort Kobayashi, Yuki
collection PubMed
description We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney rats and Parkinson’s disease mice. Rats are fed with control or Si-based agent-containing diet for 8 weeks. Si-based agent is found to greatly suppress the development of renal failure and the parameters of oxidative stress. Treatment with Si-based agent in a mouse model of hemi-Parkinson’s disease induced by 6-hydroxydopamine attenuated degeneration of dopaminergic neurons and prevented impairment of motor balance and coordination. These findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen.
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spelling pubmed-71251172020-04-08 Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent Kobayashi, Yuki Imamura, Ryoichi Koyama, Yoshihisa Kondo, Makoto Kobayashi, Hikaru Nonomura, Norio Shimada, Shoichi Sci Rep Article We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney rats and Parkinson’s disease mice. Rats are fed with control or Si-based agent-containing diet for 8 weeks. Si-based agent is found to greatly suppress the development of renal failure and the parameters of oxidative stress. Treatment with Si-based agent in a mouse model of hemi-Parkinson’s disease induced by 6-hydroxydopamine attenuated degeneration of dopaminergic neurons and prevented impairment of motor balance and coordination. These findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen. Nature Publishing Group UK 2020-04-03 /pmc/articles/PMC7125117/ /pubmed/32246095 http://dx.doi.org/10.1038/s41598-020-62755-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kobayashi, Yuki
Imamura, Ryoichi
Koyama, Yoshihisa
Kondo, Makoto
Kobayashi, Hikaru
Nonomura, Norio
Shimada, Shoichi
Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title_full Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title_fullStr Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title_full_unstemmed Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title_short Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
title_sort renoprotective and neuroprotective effects of enteric hydrogen generation from si-based agent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125117/
https://www.ncbi.nlm.nih.gov/pubmed/32246095
http://dx.doi.org/10.1038/s41598-020-62755-9
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