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Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic Kras(G12D) and NLRP3 inflammasome...

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Detalles Bibliográficos
Autores principales:	Hamarsheh, Shaima’a, Osswald, Lena, Saller, Benedikt S., Unger, Susanne, De Feo, Donatella, Vinnakota, Janaki Manoja, Konantz, Martina, Uhl, Franziska M., Becker, Heiko, Lübbert, Michael, Shoumariyeh, Khalid, Schürch, Christoph, Andrieux, Geoffroy, Venhoff, Nils, Schmitt-Graeff, Annette, Duquesne, Sandra, Pfeifer, Dietmar, Cooper, Matthew A., Lengerke, Claudia, Boerries, Melanie, Duyster, Justus, Niemeyer, Charlotte M., Erlacher, Miriam, Blazar, Bruce R., Becher, Burkard, Groß, Olaf, Brummer, Tilman, Zeiser, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125138/ https://www.ncbi.nlm.nih.gov/pubmed/32246016 http://dx.doi.org/10.1038/s41467-020-15497-1

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