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Diagnosis and prognosis of myocardial infarction on a plasmonic chip
Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125217/ https://www.ncbi.nlm.nih.gov/pubmed/32245966 http://dx.doi.org/10.1038/s41467-020-15487-3 |
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author | Xu, Wei Wang, Lin Zhang, Ru Sun, Xuming Huang, Lin Su, Haiyang Wei, Xunbin Chen, Chia-Chun Lou, Jiatao Dai, Hongjie Qian, Kun |
author_facet | Xu, Wei Wang, Lin Zhang, Ru Sun, Xuming Huang, Lin Su, Haiyang Wei, Xunbin Chen, Chia-Chun Lou, Jiatao Dai, Hongjie Qian, Kun |
author_sort | Xu, Wei |
collection | PubMed |
description | Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing. |
format | Online Article Text |
id | pubmed-7125217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71252172020-04-06 Diagnosis and prognosis of myocardial infarction on a plasmonic chip Xu, Wei Wang, Lin Zhang, Ru Sun, Xuming Huang, Lin Su, Haiyang Wei, Xunbin Chen, Chia-Chun Lou, Jiatao Dai, Hongjie Qian, Kun Nat Commun Article Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing. Nature Publishing Group UK 2020-04-03 /pmc/articles/PMC7125217/ /pubmed/32245966 http://dx.doi.org/10.1038/s41467-020-15487-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xu, Wei Wang, Lin Zhang, Ru Sun, Xuming Huang, Lin Su, Haiyang Wei, Xunbin Chen, Chia-Chun Lou, Jiatao Dai, Hongjie Qian, Kun Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title | Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title_full | Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title_fullStr | Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title_full_unstemmed | Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title_short | Diagnosis and prognosis of myocardial infarction on a plasmonic chip |
title_sort | diagnosis and prognosis of myocardial infarction on a plasmonic chip |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125217/ https://www.ncbi.nlm.nih.gov/pubmed/32245966 http://dx.doi.org/10.1038/s41467-020-15487-3 |
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