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MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction

We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of...

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Autores principales: Horváth, Martin, Horváthová, Veronika, Hájek, Petr, Štěchovský, Cyril, Honěk, Jakub, Šenolt, Ladislav, Veselka, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125297/
https://www.ncbi.nlm.nih.gov/pubmed/32246100
http://dx.doi.org/10.1038/s41598-020-62835-w
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author Horváth, Martin
Horváthová, Veronika
Hájek, Petr
Štěchovský, Cyril
Honěk, Jakub
Šenolt, Ladislav
Veselka, Josef
author_facet Horváth, Martin
Horváthová, Veronika
Hájek, Petr
Štěchovský, Cyril
Honěk, Jakub
Šenolt, Ladislav
Veselka, Josef
author_sort Horváth, Martin
collection PubMed
description We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without angina pectoris in whom coronary angiogram did not reveal coronary atherosclerotic disease (no coronary atherosclerosis-NCA) and a group of patients with stable angina pectoris and at least one significant coronary artery stenosis (stable coronary artery disease-SCAD). This study design allowed us to identify miRs deregulated in the setting of acute coronary artery occlusion due to VP rupture. Based on an initial large scale miR assay screening, we selected a total of 12 miRs (three study miRs and nine controls) that were tested in the study. Two of the study miRs (miR-331 and miR-151-3p) significantly distinguished STEMI patients from the control groups, while ROC analysis confirmed their suitability as biomarkers. Importantly, this was observed in patients presenting early with STEMI, even before the markers of myocardial necrosis (cardiac troponin I, miR-208 and miR-499) were elevated, which suggests that the origin of miR-331 and miR-151-3p might be in the VP. In conclusion, the study provides two novel biomarkers observed in STEMI, which may be associated with plaque rupture.
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spelling pubmed-71252972020-04-11 MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction Horváth, Martin Horváthová, Veronika Hájek, Petr Štěchovský, Cyril Honěk, Jakub Šenolt, Ladislav Veselka, Josef Sci Rep Article We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without angina pectoris in whom coronary angiogram did not reveal coronary atherosclerotic disease (no coronary atherosclerosis-NCA) and a group of patients with stable angina pectoris and at least one significant coronary artery stenosis (stable coronary artery disease-SCAD). This study design allowed us to identify miRs deregulated in the setting of acute coronary artery occlusion due to VP rupture. Based on an initial large scale miR assay screening, we selected a total of 12 miRs (three study miRs and nine controls) that were tested in the study. Two of the study miRs (miR-331 and miR-151-3p) significantly distinguished STEMI patients from the control groups, while ROC analysis confirmed their suitability as biomarkers. Importantly, this was observed in patients presenting early with STEMI, even before the markers of myocardial necrosis (cardiac troponin I, miR-208 and miR-499) were elevated, which suggests that the origin of miR-331 and miR-151-3p might be in the VP. In conclusion, the study provides two novel biomarkers observed in STEMI, which may be associated with plaque rupture. Nature Publishing Group UK 2020-04-03 /pmc/articles/PMC7125297/ /pubmed/32246100 http://dx.doi.org/10.1038/s41598-020-62835-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Horváth, Martin
Horváthová, Veronika
Hájek, Petr
Štěchovský, Cyril
Honěk, Jakub
Šenolt, Ladislav
Veselka, Josef
MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title_full MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title_fullStr MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title_full_unstemmed MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title_short MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction
title_sort microrna-331 and microrna-151-3p as biomarkers in patients with st-segment elevation myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125297/
https://www.ncbi.nlm.nih.gov/pubmed/32246100
http://dx.doi.org/10.1038/s41598-020-62835-w
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