Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation

Pathogenic mutation in BRCA1 gene is one of the most penetrant genetic predispositions towards cancer. Identification of the mutation provides important aspect in prevention and treatment of the mutation-caused cancer. Of the large quantity of genetic variants identified in human BRCA1, substantial...

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Detalles Bibliográficos
Autores principales: Sinha, Siddharth, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125325/
https://www.ncbi.nlm.nih.gov/pubmed/32257056
http://dx.doi.org/10.1016/j.csbj.2020.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125325/
https://www.ncbi.nlm.nih.gov/pubmed/32257056
http://dx.doi.org/10.1016/j.csbj.2020.03.013

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