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N(1)-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

OBJECTIVE: To explore the effects of N(1)-methylnicotinamide (MNAM) on insulin resistance and glucose metabolism in obese type 2 diabetes mellitus (T2DM) mice and regulatory mechanisms of the NAD-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box protein O1 (FOXO1) pathway. METHODS: Blood glucose...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingfan, Chen, Yu, Liu, Cong, Li, Ling, Li, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125486/ https://www.ncbi.nlm.nih.gov/pubmed/32280711 http://dx.doi.org/10.1155/2020/1080152

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