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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

METHODS: A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m(2)) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. RESULTS: Of 6285 lean participants enrolled, 654 NAF...

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Autores principales: Zhang, Ya-Nan, Wang, Qin-Qiu, Chen, Yi-Shu, Shen, Chao, Xu, Cheng-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125489/
https://www.ncbi.nlm.nih.gov/pubmed/32273892
http://dx.doi.org/10.1155/2020/5953461
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author Zhang, Ya-Nan
Wang, Qin-Qiu
Chen, Yi-Shu
Shen, Chao
Xu, Cheng-Fu
author_facet Zhang, Ya-Nan
Wang, Qin-Qiu
Chen, Yi-Shu
Shen, Chao
Xu, Cheng-Fu
author_sort Zhang, Ya-Nan
collection PubMed
description METHODS: A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m(2)) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. RESULTS: Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P < 0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P < 0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P < 0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. CONCLUSIONS: UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.
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spelling pubmed-71254892020-04-09 Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults Zhang, Ya-Nan Wang, Qin-Qiu Chen, Yi-Shu Shen, Chao Xu, Cheng-Fu Int J Endocrinol Research Article METHODS: A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m(2)) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. RESULTS: Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P < 0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P < 0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P < 0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. CONCLUSIONS: UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults. Hindawi 2020-03-23 /pmc/articles/PMC7125489/ /pubmed/32273892 http://dx.doi.org/10.1155/2020/5953461 Text en Copyright © 2020 Ya-Nan Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Ya-Nan
Wang, Qin-Qiu
Chen, Yi-Shu
Shen, Chao
Xu, Cheng-Fu
Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title_full Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title_fullStr Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title_full_unstemmed Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title_short Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults
title_sort association between serum uric acid to hdl-cholesterol ratio and nonalcoholic fatty liver disease in lean chinese adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125489/
https://www.ncbi.nlm.nih.gov/pubmed/32273892
http://dx.doi.org/10.1155/2020/5953461
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