Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of oc...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Ming-xuan, Zhao, Jing, Zhang, Hong, Li, Ke, Niu, Ling-zhi, Wang, Yuan-ping, Zheng, Ya-juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125500/
https://www.ncbi.nlm.nih.gov/pubmed/32273949
http://dx.doi.org/10.1155/2020/9410952
_version_ 1783515958870016000
author Wang, Ming-xuan
Zhao, Jing
Zhang, Hong
Li, Ke
Niu, Ling-zhi
Wang, Yuan-ping
Zheng, Ya-juan
author_facet Wang, Ming-xuan
Zhao, Jing
Zhang, Hong
Li, Ke
Niu, Ling-zhi
Wang, Yuan-ping
Zheng, Ya-juan
author_sort Wang, Ming-xuan
collection PubMed
description Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.
format Online
Article
Text
id pubmed-7125500
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-71255002020-04-09 Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update Wang, Ming-xuan Zhao, Jing Zhang, Hong Li, Ke Niu, Ling-zhi Wang, Yuan-ping Zheng, Ya-juan Oxid Med Cell Longev Review Article Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases. Hindawi 2020-03-23 /pmc/articles/PMC7125500/ /pubmed/32273949 http://dx.doi.org/10.1155/2020/9410952 Text en Copyright © 2020 Ming-xuan Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Ming-xuan
Zhao, Jing
Zhang, Hong
Li, Ke
Niu, Ling-zhi
Wang, Yuan-ping
Zheng, Ya-juan
Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title_full Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title_fullStr Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title_full_unstemmed Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title_short Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update
title_sort potential protective and therapeutic roles of the nrf2 pathway in ocular diseases: an update
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125500/
https://www.ncbi.nlm.nih.gov/pubmed/32273949
http://dx.doi.org/10.1155/2020/9410952
work_keys_str_mv AT wangmingxuan potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT zhaojing potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT zhanghong potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT like potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT niulingzhi potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT wangyuanping potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate
AT zhengyajuan potentialprotectiveandtherapeuticrolesofthenrf2pathwayinoculardiseasesanupdate

Ejemplares similares