Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer

Our previous work revealed that Nrf1α exerts a tumor-repressing effect because its genomic loss (to yield Nrf1α(−/−)) results in oncogenic activation of Nrf2 and target genes. Interestingly, β-catenin is concurrently activated by loss of Nrf1α in a way similar to β-catenin-driven liver tumor. Howeve...

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Detalles Bibliográficos
Autores principales: Chen, Jiayu, Wang, Meng, Xiang, Yuancai, Ru, Xufang, Ren, Yonggang, Liu, Xiping, Qiu, Lu, Zhang, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125503/
https://www.ncbi.nlm.nih.gov/pubmed/32273945
http://dx.doi.org/10.1155/2020/5138539

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