Complement Receptor 1: Disease associations and therapeutic implications

Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such disea...

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Detalles Bibliográficos
Autores principales: Khera, Rohan, Das, Nibhriti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. Published by Elsevier Ltd. 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125513/
https://www.ncbi.nlm.nih.gov/pubmed/19004497
http://dx.doi.org/10.1016/j.molimm.2008.09.026
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author Khera, Rohan
Das, Nibhriti
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Das, Nibhriti
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description Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1.
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spelling pubmed-71255132020-04-08 Complement Receptor 1: Disease associations and therapeutic implications Khera, Rohan Das, Nibhriti Mol Immunol Review Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1. Elsevier Ltd. Published by Elsevier Ltd. 2009-02 2008-11-11 /pmc/articles/PMC7125513/ /pubmed/19004497 http://dx.doi.org/10.1016/j.molimm.2008.09.026 Text en Copyright © 2008 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Khera, Rohan
Das, Nibhriti
Complement Receptor 1: Disease associations and therapeutic implications
title Complement Receptor 1: Disease associations and therapeutic implications
title_full Complement Receptor 1: Disease associations and therapeutic implications
title_fullStr Complement Receptor 1: Disease associations and therapeutic implications
title_full_unstemmed Complement Receptor 1: Disease associations and therapeutic implications
title_short Complement Receptor 1: Disease associations and therapeutic implications
title_sort complement receptor 1: disease associations and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125513/
https://www.ncbi.nlm.nih.gov/pubmed/19004497
http://dx.doi.org/10.1016/j.molimm.2008.09.026
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