Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

Cycloadditions of N-substituted C-(diethoxyphosphoryl)nitrones to N-allylated quinazoline-2,4-diones functionalized at N3 with substituted benzoyl or benzyl groups proceeded with moderate to good diastereoselectivities (d.e. 28–68%). The synthesized isoxazolidine phosphonates were assessed for the a...

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Detalles Bibliográficos
Autores principales: Piotrowska, Dorota G., Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Łysakowska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125519/
https://www.ncbi.nlm.nih.gov/pubmed/27750154
http://dx.doi.org/10.1016/j.ejmech.2016.10.002

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