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Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis....
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125537/ https://www.ncbi.nlm.nih.gov/pubmed/20089402 http://dx.doi.org/10.1016/j.bmcl.2009.12.090 |