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Heparin enhances the furin cleavage of HIV‐1 gp160 peptides

Infectious HIV‐1 requires gp160 cleavage by furin at the REKR(511)↓ motif (site1) into the gp120/gp41 complex, whereas the KAKR(503) (site2) sequence remains uncleaved. We synthesized 41mer and 51mer peptides, comprising site1 and site2, to study their conformation and in vitro furin processing. We...

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Detalles Bibliográficos
Autores principales:	Pasquato, A., Dettin, M., Basak, A., Gambaretto, R., Tonin, L., Seidah, N.G., Di Bello, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2007
Materias:	Short Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125586/ https://www.ncbi.nlm.nih.gov/pubmed/18037384 http://dx.doi.org/10.1016/j.febslet.2007.11.050

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