Molecularly imprinted polymers for the selective extraction of glycyrrhizic acid from liquorice roots

A new Molecularly Imprinted Solid Phase Extraction (MISPE) protocol was developed for the selective extraction and purification of glycyrrhizic acid (GL) from liquorice roots. Non-covalent MIP were synthesized using methacrylic acid (MAA), 2-(dimethylamino)ethyl methacrilate (DMAEM) or 2-hydroxyethy...

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Detalles Bibliográficos
Autores principales: Cirillo, Giuseppe, Curcio, Manuela, Parisi, Ortensia Ilaria, Puoci, Francesco, Iemma, Francesca, Spizzirri, Umile Gianfranco, Restuccia, Donatella, Picci, Nevio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2011
Materias:
Analytical Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125629/
http://dx.doi.org/10.1016/j.foodchem.2010.09.077
Descripción
Sumario:A new Molecularly Imprinted Solid Phase Extraction (MISPE) protocol was developed for the selective extraction and purification of glycyrrhizic acid (GL) from liquorice roots. Non-covalent MIP were synthesized using methacrylic acid (MAA), 2-(dimethylamino)ethyl methacrilate (DMAEM) or 2-hydroxyethylmetacrylate (HEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. After the evaluation of the selectivity of the GL imprinted polymers, the performance of these materials as Solid Phase Extraction (SPE) sorbents was investigated. MIP having HEMA as functional monomer were found to be able to selectively extract almost 80% of GL content in liquorice roots. The proposed MISPE-HPLC procedure has good precision, thus it can be successfully used for the purification of GL from natural sources.

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