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Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum
The aim of this research was to evaluate the influence of maternal cells from colostrum on the development and function of the innate immune response in Holstein calves. Calves were divided into 2 groups: COL + (n = 10) received fresh colostrum; and COL − (n = 10) which received frozen colostrum con...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125648/ https://www.ncbi.nlm.nih.gov/pubmed/28135671 http://dx.doi.org/10.1016/j.rvsc.2017.01.008 |
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author | Costa, Juliana França Dos Reis Novo, Sylvia Marquart Fontes Baccili, Camila Costa Sobreira, Natália Meirelles Hurley, David John Gomes, Viviani |
author_facet | Costa, Juliana França Dos Reis Novo, Sylvia Marquart Fontes Baccili, Camila Costa Sobreira, Natália Meirelles Hurley, David John Gomes, Viviani |
author_sort | Costa, Juliana França Dos Reis |
collection | PubMed |
description | The aim of this research was to evaluate the influence of maternal cells from colostrum on the development and function of the innate immune response in Holstein calves. Calves were divided into 2 groups: COL + (n = 10) received fresh colostrum; and COL − (n = 10) which received frozen colostrum containing no viable cells. The calves were assessed before colostrum intake (D0), 48 h of age (D2), and weekly from D7 up to D28. Blood samples were collected for analysis of the distribution of leukocytes, cellular phenotype and in vitro granulocyte function. COL + calves tended to have a high number of neutrophils on D7 (p = 0.073). COL − calves took up significantly more Escherichia coli (measured as MFI) on D7 (p = 0.034). Endogenous production of radicals (as percentage of cells) tended to be higher in COL − calves on D14 (p = 0.061). The intensity of endogenous reactive oxygen species (ROS) produced by granulocytes tended to be higher in COL + calves on D21 (p = 0.094). Overall, ROS production (percent of cells, and MFI) induced by Staphylococcus aureus and Escherichia coli were higher in COL + calves than COL − calves. It was our observation that COL + calves developed an innate immune response more quickly and efficiently after natural exposure to pathogens after birth. In contrast, COL − calves mounted an innate response more slowly that yielded a persistent inflammatory response after natural exposure to these bacteria agents. This research provides evidence of an advantage to the calf of receiving fresh colostrum on the development and function of the innate immune system. |
format | Online Article Text |
id | pubmed-7125648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71256482020-04-08 Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum Costa, Juliana França Dos Reis Novo, Sylvia Marquart Fontes Baccili, Camila Costa Sobreira, Natália Meirelles Hurley, David John Gomes, Viviani Res Vet Sci Article The aim of this research was to evaluate the influence of maternal cells from colostrum on the development and function of the innate immune response in Holstein calves. Calves were divided into 2 groups: COL + (n = 10) received fresh colostrum; and COL − (n = 10) which received frozen colostrum containing no viable cells. The calves were assessed before colostrum intake (D0), 48 h of age (D2), and weekly from D7 up to D28. Blood samples were collected for analysis of the distribution of leukocytes, cellular phenotype and in vitro granulocyte function. COL + calves tended to have a high number of neutrophils on D7 (p = 0.073). COL − calves took up significantly more Escherichia coli (measured as MFI) on D7 (p = 0.034). Endogenous production of radicals (as percentage of cells) tended to be higher in COL − calves on D14 (p = 0.061). The intensity of endogenous reactive oxygen species (ROS) produced by granulocytes tended to be higher in COL + calves on D21 (p = 0.094). Overall, ROS production (percent of cells, and MFI) induced by Staphylococcus aureus and Escherichia coli were higher in COL + calves than COL − calves. It was our observation that COL + calves developed an innate immune response more quickly and efficiently after natural exposure to pathogens after birth. In contrast, COL − calves mounted an innate response more slowly that yielded a persistent inflammatory response after natural exposure to these bacteria agents. This research provides evidence of an advantage to the calf of receiving fresh colostrum on the development and function of the innate immune system. Elsevier Ltd. 2017-12 2017-01-17 /pmc/articles/PMC7125648/ /pubmed/28135671 http://dx.doi.org/10.1016/j.rvsc.2017.01.008 Text en © 2017 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Costa, Juliana França Dos Reis Novo, Sylvia Marquart Fontes Baccili, Camila Costa Sobreira, Natália Meirelles Hurley, David John Gomes, Viviani Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title | Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title_full | Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title_fullStr | Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title_full_unstemmed | Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title_short | Innate immune response in neonate Holstein heifer calves fed fresh or frozen colostrum |
title_sort | innate immune response in neonate holstein heifer calves fed fresh or frozen colostrum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125648/ https://www.ncbi.nlm.nih.gov/pubmed/28135671 http://dx.doi.org/10.1016/j.rvsc.2017.01.008 |
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