Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months....

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Autores principales: Chen, Guan-Jie, Colombo, Lucas L., Lopez, Maria C., Watson, Ronald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ireland Ltd. 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125649/
https://www.ncbi.nlm.nih.gov/pubmed/7513605
http://dx.doi.org/10.1016/0304-3835(93)90236-3
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author Chen, Guan-Jie
Colombo, Lucas L.
Lopez, Maria C.
Watson, Ronald R.
author_facet Chen, Guan-Jie
Colombo, Lucas L.
Lopez, Maria C.
Watson, Ronald R.
author_sort Chen, Guan-Jie
collection PubMed
description Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.
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spelling pubmed-71256492020-04-08 Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice Chen, Guan-Jie Colombo, Lucas L. Lopez, Maria C. Watson, Ronald R. Cancer Lett Article Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system. Published by Elsevier Ireland Ltd. 1993-11-01 2004-03-17 /pmc/articles/PMC7125649/ /pubmed/7513605 http://dx.doi.org/10.1016/0304-3835(93)90236-3 Text en Copyright © 1993 Published by Elsevier Ireland Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chen, Guan-Jie
Colombo, Lucas L.
Lopez, Maria C.
Watson, Ronald R.
Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title_full Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title_fullStr Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title_full_unstemmed Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title_short Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice
title_sort reduction of tumor necrosis factor production by splenocytes from v-ha-ras oncogene-bearing mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125649/
https://www.ncbi.nlm.nih.gov/pubmed/7513605
http://dx.doi.org/10.1016/0304-3835(93)90236-3
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