Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog

Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activ...

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Detalles Bibliográficos
Autores principales: Leiva, Rosana, Gazzarrini, Sabrina, Esplugas, Roser, Moroni, Anna, Naesens, Lieve, Sureda, Francesc X., Vázquez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125674/
https://www.ncbi.nlm.nih.gov/pubmed/32287445
http://dx.doi.org/10.1016/j.tetlet.2015.01.160
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author Leiva, Rosana
Gazzarrini, Sabrina
Esplugas, Roser
Moroni, Anna
Naesens, Lieve
Sureda, Francesc X.
Vázquez, Santiago
author_facet Leiva, Rosana
Gazzarrini, Sabrina
Esplugas, Roser
Moroni, Anna
Naesens, Lieve
Sureda, Francesc X.
Vázquez, Santiago
author_sort Leiva, Rosana
collection PubMed
description Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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spelling pubmed-71256742020-04-08 Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog Leiva, Rosana Gazzarrini, Sabrina Esplugas, Roser Moroni, Anna Naesens, Lieve Sureda, Francesc X. Vázquez, Santiago Tetrahedron Lett Article Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist. Elsevier Ltd. 2015-03-04 2015-01-31 /pmc/articles/PMC7125674/ /pubmed/32287445 http://dx.doi.org/10.1016/j.tetlet.2015.01.160 Text en Copyright © 2015 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Leiva, Rosana
Gazzarrini, Sabrina
Esplugas, Roser
Moroni, Anna
Naesens, Lieve
Sureda, Francesc X.
Vázquez, Santiago
Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title_full Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title_fullStr Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title_full_unstemmed Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title_short Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
title_sort ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125674/
https://www.ncbi.nlm.nih.gov/pubmed/32287445
http://dx.doi.org/10.1016/j.tetlet.2015.01.160
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