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Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activ...
Autores principales: | Leiva, Rosana, Gazzarrini, Sabrina, Esplugas, Roser, Moroni, Anna, Naesens, Lieve, Sureda, Francesc X., Vázquez, Santiago |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125674/ https://www.ncbi.nlm.nih.gov/pubmed/32287445 http://dx.doi.org/10.1016/j.tetlet.2015.01.160 |
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