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Quasispecies and its impact on viral hepatitis

Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of m...

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Detalles Bibliográficos
Autores principales: Domingo, Esteban, Gomez, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125676/
https://www.ncbi.nlm.nih.gov/pubmed/17349710
http://dx.doi.org/10.1016/j.virusres.2007.02.001
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author Domingo, Esteban
Gomez, Jordi
author_facet Domingo, Esteban
Gomez, Jordi
author_sort Domingo, Esteban
collection PubMed
description Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional properties, and alterations of mutant spectrum complexity that can affect disease progression or response to treatment. The widespread occurrence of resistance to antiviral drugs encourages new strategies to control hepatic viral disease such as combination therapies and lethal mutagenesis. In particular, ribavirin may be exerting in some cases its antiviral activity with participation of its mutagenic action. Despite many unanswered questions, here we document that quasispecies dynamics has provided an interpretation of the adaptability of the hepatitis viruses, with features conceptually similar to those observed with other RNA viruses, a reflection of the common underlying Darwinian principles.
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spelling pubmed-71256762020-04-08 Quasispecies and its impact on viral hepatitis Domingo, Esteban Gomez, Jordi Virus Res Article Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional properties, and alterations of mutant spectrum complexity that can affect disease progression or response to treatment. The widespread occurrence of resistance to antiviral drugs encourages new strategies to control hepatic viral disease such as combination therapies and lethal mutagenesis. In particular, ribavirin may be exerting in some cases its antiviral activity with participation of its mutagenic action. Despite many unanswered questions, here we document that quasispecies dynamics has provided an interpretation of the adaptability of the hepatitis viruses, with features conceptually similar to those observed with other RNA viruses, a reflection of the common underlying Darwinian principles. Elsevier B.V. 2007-08 2007-03-08 /pmc/articles/PMC7125676/ /pubmed/17349710 http://dx.doi.org/10.1016/j.virusres.2007.02.001 Text en Copyright © 2007 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Domingo, Esteban
Gomez, Jordi
Quasispecies and its impact on viral hepatitis
title Quasispecies and its impact on viral hepatitis
title_full Quasispecies and its impact on viral hepatitis
title_fullStr Quasispecies and its impact on viral hepatitis
title_full_unstemmed Quasispecies and its impact on viral hepatitis
title_short Quasispecies and its impact on viral hepatitis
title_sort quasispecies and its impact on viral hepatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125676/
https://www.ncbi.nlm.nih.gov/pubmed/17349710
http://dx.doi.org/10.1016/j.virusres.2007.02.001
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