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Quasispecies and its impact on viral hepatitis
Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125676/ https://www.ncbi.nlm.nih.gov/pubmed/17349710 http://dx.doi.org/10.1016/j.virusres.2007.02.001 |
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author | Domingo, Esteban Gomez, Jordi |
author_facet | Domingo, Esteban Gomez, Jordi |
author_sort | Domingo, Esteban |
collection | PubMed |
description | Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional properties, and alterations of mutant spectrum complexity that can affect disease progression or response to treatment. The widespread occurrence of resistance to antiviral drugs encourages new strategies to control hepatic viral disease such as combination therapies and lethal mutagenesis. In particular, ribavirin may be exerting in some cases its antiviral activity with participation of its mutagenic action. Despite many unanswered questions, here we document that quasispecies dynamics has provided an interpretation of the adaptability of the hepatitis viruses, with features conceptually similar to those observed with other RNA viruses, a reflection of the common underlying Darwinian principles. |
format | Online Article Text |
id | pubmed-7125676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71256762020-04-08 Quasispecies and its impact on viral hepatitis Domingo, Esteban Gomez, Jordi Virus Res Article Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional properties, and alterations of mutant spectrum complexity that can affect disease progression or response to treatment. The widespread occurrence of resistance to antiviral drugs encourages new strategies to control hepatic viral disease such as combination therapies and lethal mutagenesis. In particular, ribavirin may be exerting in some cases its antiviral activity with participation of its mutagenic action. Despite many unanswered questions, here we document that quasispecies dynamics has provided an interpretation of the adaptability of the hepatitis viruses, with features conceptually similar to those observed with other RNA viruses, a reflection of the common underlying Darwinian principles. Elsevier B.V. 2007-08 2007-03-08 /pmc/articles/PMC7125676/ /pubmed/17349710 http://dx.doi.org/10.1016/j.virusres.2007.02.001 Text en Copyright © 2007 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Domingo, Esteban Gomez, Jordi Quasispecies and its impact on viral hepatitis |
title | Quasispecies and its impact on viral hepatitis |
title_full | Quasispecies and its impact on viral hepatitis |
title_fullStr | Quasispecies and its impact on viral hepatitis |
title_full_unstemmed | Quasispecies and its impact on viral hepatitis |
title_short | Quasispecies and its impact on viral hepatitis |
title_sort | quasispecies and its impact on viral hepatitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125676/ https://www.ncbi.nlm.nih.gov/pubmed/17349710 http://dx.doi.org/10.1016/j.virusres.2007.02.001 |
work_keys_str_mv | AT domingoesteban quasispeciesanditsimpactonviralhepatitis AT gomezjordi quasispeciesanditsimpactonviralhepatitis |