Tissue distribution of the antigenic variants of canine parvovirus type 2 in dogs

Twelve dogs dead as consequence of natural infection caused by canine parvovirus (CPV) type 2a (n = 4), type 2b (n = 4) or type 2c (n = 4) were investigated for determining the viral DNA loads in different tissue samples. By means of a real-time PCR assay, CPV DNA was detected in all tissues examine...

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Detalles Bibliográficos
Autores principales: Decaro, Nicola, Martella, Vito, Elia, Gabriella, Desario, Costantina, Campolo, Marco, Lorusso, Eleonora, Colaianni, Maria Loredana, Lorusso, Alessio, Buonavoglia, Canio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125685/
https://www.ncbi.nlm.nih.gov/pubmed/17169509
http://dx.doi.org/10.1016/j.vetmic.2006.11.005
Descripción
Sumario:Twelve dogs dead as consequence of natural infection caused by canine parvovirus (CPV) type 2a (n = 4), type 2b (n = 4) or type 2c (n = 4) were investigated for determining the viral DNA loads in different tissue samples. By means of a real-time PCR assay, CPV DNA was detected in all tissues examined, with the highest titres observed in the lymphoid tissue and the lowest loads in the urinary tract. Surprisingly, the nervous tissue was found to contain considerable amounts of CPV nucleic acid. Similar patterns of tissue distribution were observed in all the examined dogs irrespective of the antigenic variant causing the disease.

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