Molecular characterization and pathogenicity of a genogroup GVI feline norovirus

Norovirus (NoV) has been classified into 6 genogroups, GI-GVI. In the present study, we identified novel feline NoV (FNoV) M49-1 strain. The C-terminal of RNA-dependent RNA polymerase of the FNoV M49-1 strain was highly homologous with GIV FNoV and GIV lion norovirus, whereas VP1 was highly homologo...

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Autores principales: Takano, Tomomi, Kusuhara, Hajime, Kuroishi, Akira, Takashina, Midori, Doki, Tomoyoshi, Nishinaka, Takamichi, Hohdatsu, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125706/
https://www.ncbi.nlm.nih.gov/pubmed/26026731
http://dx.doi.org/10.1016/j.vetmic.2015.05.018
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author Takano, Tomomi
Kusuhara, Hajime
Kuroishi, Akira
Takashina, Midori
Doki, Tomoyoshi
Nishinaka, Takamichi
Hohdatsu, Tsutomu
author_facet Takano, Tomomi
Kusuhara, Hajime
Kuroishi, Akira
Takashina, Midori
Doki, Tomoyoshi
Nishinaka, Takamichi
Hohdatsu, Tsutomu
author_sort Takano, Tomomi
collection PubMed
description Norovirus (NoV) has been classified into 6 genogroups, GI-GVI. In the present study, we identified novel feline NoV (FNoV) M49-1 strain. The C-terminal of RNA-dependent RNA polymerase of the FNoV M49-1 strain was highly homologous with GIV FNoV and GIV lion norovirus, whereas VP1 was highly homologous with GVI canine NoV (CNoV). Based on the results of the Simplot analysis, the FNoV M49-1 strain may have been produced by recombination between GIV.2 FNoV and GVI.1 CNoV. In addition, specific pathogen-free cats inoculated with FNoV gene-positive-fecal samples developed diarrhea symptoms, and the viral gene was detected in their feces and blood.
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spelling pubmed-71257062020-04-08 Molecular characterization and pathogenicity of a genogroup GVI feline norovirus Takano, Tomomi Kusuhara, Hajime Kuroishi, Akira Takashina, Midori Doki, Tomoyoshi Nishinaka, Takamichi Hohdatsu, Tsutomu Vet Microbiol Article Norovirus (NoV) has been classified into 6 genogroups, GI-GVI. In the present study, we identified novel feline NoV (FNoV) M49-1 strain. The C-terminal of RNA-dependent RNA polymerase of the FNoV M49-1 strain was highly homologous with GIV FNoV and GIV lion norovirus, whereas VP1 was highly homologous with GVI canine NoV (CNoV). Based on the results of the Simplot analysis, the FNoV M49-1 strain may have been produced by recombination between GIV.2 FNoV and GVI.1 CNoV. In addition, specific pathogen-free cats inoculated with FNoV gene-positive-fecal samples developed diarrhea symptoms, and the viral gene was detected in their feces and blood. Elsevier B.V. 2015-08-05 2015-05-27 /pmc/articles/PMC7125706/ /pubmed/26026731 http://dx.doi.org/10.1016/j.vetmic.2015.05.018 Text en Copyright © 2015 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Takano, Tomomi
Kusuhara, Hajime
Kuroishi, Akira
Takashina, Midori
Doki, Tomoyoshi
Nishinaka, Takamichi
Hohdatsu, Tsutomu
Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title_full Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title_fullStr Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title_full_unstemmed Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title_short Molecular characterization and pathogenicity of a genogroup GVI feline norovirus
title_sort molecular characterization and pathogenicity of a genogroup gvi feline norovirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125706/
https://www.ncbi.nlm.nih.gov/pubmed/26026731
http://dx.doi.org/10.1016/j.vetmic.2015.05.018
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