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Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections
Sinupret(®), a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antivi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier GmbH.
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125718/ https://www.ncbi.nlm.nih.gov/pubmed/22112724 http://dx.doi.org/10.1016/j.phymed.2011.10.010 |
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author | Glatthaar-Saalmüller, B. Rauchhaus, U. Rode, S. Haunschild, J. Saalmüller, A. |
author_facet | Glatthaar-Saalmüller, B. Rauchhaus, U. Rode, S. Haunschild, J. Saalmüller, A. |
author_sort | Glatthaar-Saalmüller, B. |
collection | PubMed |
description | Sinupret(®), a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antiviral activity. Therefore experiments have been performed to measure the antiviral activity of Sinupret(®) oral drops (hereinafter referred to as “oral drops”) and Sinupret(®) dry extract (hereinafter referred to as “dry extract”), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/California/07/2009 (H1N1) virus (pFluA), parainfluenza type 3 virus (Para 3), respiratory syncytial virus, strain Long (RSV), human rhinovirus B subtype 14 (HRV 14), coxsackievirus subtype A9 (CA9), and adenovirus C subtype 5 (Adeno 5). Concentration-dependent antiviral activity (EC(50) between 13.8 and 124.8 μg/ml) of Sinupret(®) was observed against RNA as well as DNA viruses independent of a viral envelope. Remarkable antiviral activity was shown against Adeno 5, HRV 14 and RSV in which dry extract was significantly superior to oral drops. This could be ascertained with different assays as plaque-reduction assays in plaque forming units (PFU), the analyses of a cytopathogenic effect (CPE) and with enzyme immunoassays (ELISA) to determine the amount of newly synthesised virus. Our results demonstrate that Sinupret(®) shows a broad spectrum of antiviral activity in vitro against viruses commonly known to cause respiratory infections. |
format | Online Article Text |
id | pubmed-7125718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Elsevier GmbH. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71257182020-04-08 Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections Glatthaar-Saalmüller, B. Rauchhaus, U. Rode, S. Haunschild, J. Saalmüller, A. Phytomedicine Article Sinupret(®), a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antiviral activity. Therefore experiments have been performed to measure the antiviral activity of Sinupret(®) oral drops (hereinafter referred to as “oral drops”) and Sinupret(®) dry extract (hereinafter referred to as “dry extract”), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/California/07/2009 (H1N1) virus (pFluA), parainfluenza type 3 virus (Para 3), respiratory syncytial virus, strain Long (RSV), human rhinovirus B subtype 14 (HRV 14), coxsackievirus subtype A9 (CA9), and adenovirus C subtype 5 (Adeno 5). Concentration-dependent antiviral activity (EC(50) between 13.8 and 124.8 μg/ml) of Sinupret(®) was observed against RNA as well as DNA viruses independent of a viral envelope. Remarkable antiviral activity was shown against Adeno 5, HRV 14 and RSV in which dry extract was significantly superior to oral drops. This could be ascertained with different assays as plaque-reduction assays in plaque forming units (PFU), the analyses of a cytopathogenic effect (CPE) and with enzyme immunoassays (ELISA) to determine the amount of newly synthesised virus. Our results demonstrate that Sinupret(®) shows a broad spectrum of antiviral activity in vitro against viruses commonly known to cause respiratory infections. Elsevier GmbH. 2011-12-15 2011-11-21 /pmc/articles/PMC7125718/ /pubmed/22112724 http://dx.doi.org/10.1016/j.phymed.2011.10.010 Text en Copyright © 2011 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Glatthaar-Saalmüller, B. Rauchhaus, U. Rode, S. Haunschild, J. Saalmüller, A. Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title | Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title_full | Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title_fullStr | Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title_full_unstemmed | Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title_short | Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret(®) against viruses causing respiratory infections |
title_sort | antiviral activity in vitro of two preparations of the herbal medicinal product sinupret(®) against viruses causing respiratory infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125718/ https://www.ncbi.nlm.nih.gov/pubmed/22112724 http://dx.doi.org/10.1016/j.phymed.2011.10.010 |
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