Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()

Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. T...

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Detalles Bibliográficos
Autores principales: Yadav, Prem P., Gupta, Prasoon, Chaturvedi, A.K., Shukla, P.K., Maurya, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125744/
https://www.ncbi.nlm.nih.gov/pubmed/15698765
http://dx.doi.org/10.1016/j.bmc.2004.12.032
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author Yadav, Prem P.
Gupta, Prasoon
Chaturvedi, A.K.
Shukla, P.K.
Maurya, Rakesh
author_facet Yadav, Prem P.
Gupta, Prasoon
Chaturvedi, A.K.
Shukla, P.K.
Maurya, Rakesh
author_sort Yadav, Prem P.
collection PubMed
description Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. The compound 19 was the best and showed comparable MICs to the known compound karanjin. Compounds 5, 12, 14 and 22 also showed comparable MIC to karanjin.
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spelling pubmed-71257442020-04-08 Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents() Yadav, Prem P. Gupta, Prasoon Chaturvedi, A.K. Shukla, P.K. Maurya, Rakesh Bioorg Med Chem Article Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. The compound 19 was the best and showed comparable MICs to the known compound karanjin. Compounds 5, 12, 14 and 22 also showed comparable MIC to karanjin. Elsevier Ltd. 2005-03-01 2005-01-21 /pmc/articles/PMC7125744/ /pubmed/15698765 http://dx.doi.org/10.1016/j.bmc.2004.12.032 Text en Copyright © 2005 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yadav, Prem P.
Gupta, Prasoon
Chaturvedi, A.K.
Shukla, P.K.
Maurya, Rakesh
Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title_full Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title_fullStr Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title_full_unstemmed Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title_short Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
title_sort synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125744/
https://www.ncbi.nlm.nih.gov/pubmed/15698765
http://dx.doi.org/10.1016/j.bmc.2004.12.032
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