Knocking down Disease with siRNAs

Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.

Detalles Bibliográficos
Autores principales: Dykxhoorn, Derek M., Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Essay
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125751/
https://www.ncbi.nlm.nih.gov/pubmed/16873051
http://dx.doi.org/10.1016/j.cell.2006.07.007
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author Dykxhoorn, Derek M.
Lieberman, Judy
author_facet Dykxhoorn, Derek M.
Lieberman, Judy
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description Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.
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spelling pubmed-71257512020-04-08 Knocking down Disease with siRNAs Dykxhoorn, Derek M. Lieberman, Judy Cell Essay Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them. Elsevier Inc. 2006-07-28 2006-07-27 /pmc/articles/PMC7125751/ /pubmed/16873051 http://dx.doi.org/10.1016/j.cell.2006.07.007 Text en Copyright © 2006 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Essay
Dykxhoorn, Derek M.
Lieberman, Judy
Knocking down Disease with siRNAs
title Knocking down Disease with siRNAs
title_full Knocking down Disease with siRNAs
title_fullStr Knocking down Disease with siRNAs
title_full_unstemmed Knocking down Disease with siRNAs
title_short Knocking down Disease with siRNAs
title_sort knocking down disease with sirnas
topic Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125751/
https://www.ncbi.nlm.nih.gov/pubmed/16873051
http://dx.doi.org/10.1016/j.cell.2006.07.007
work_keys_str_mv AT dykxhoornderekm knockingdowndiseasewithsirnas
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