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Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors
Interferons represent a protein family with pleiotropic functions including immunomodulatory, cytostatic, and cytotoxic activities. Based on these effects, interferons are involved in innate as well as adaptive immunity, thereby shaping the tumor host immune responses. These cytokines, alone or in c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier Inc.
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125809/ https://www.ncbi.nlm.nih.gov/pubmed/19055946 http://dx.doi.org/10.1016/S0065-230X(08)00407-7 |
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author | Seliger, Barbara Ruiz‐Cabello, Francisco Garrido, Federico |
author_facet | Seliger, Barbara Ruiz‐Cabello, Francisco Garrido, Federico |
author_sort | Seliger, Barbara |
collection | PubMed |
description | Interferons represent a protein family with pleiotropic functions including immunomodulatory, cytostatic, and cytotoxic activities. Based on these effects, interferons are involved in innate as well as adaptive immunity, thereby shaping the tumor host immune responses. These cytokines, alone or in combination, have been successfully implemented for the treatment of some malignancies. However, it has been recently demonstrated that tumor cells could be resistant to interferon treatment, which may be associated with an escape of tumor cells from immune surveillance. Therefore, the aim of this chapter is to summarize the frequency of impaired interferon signal transduction, their underlying molecular mechanisms, and their clinical relevance. |
format | Online Article Text |
id | pubmed-7125809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71258092020-04-06 Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors Seliger, Barbara Ruiz‐Cabello, Francisco Garrido, Federico Adv Cancer Res Article Interferons represent a protein family with pleiotropic functions including immunomodulatory, cytostatic, and cytotoxic activities. Based on these effects, interferons are involved in innate as well as adaptive immunity, thereby shaping the tumor host immune responses. These cytokines, alone or in combination, have been successfully implemented for the treatment of some malignancies. However, it has been recently demonstrated that tumor cells could be resistant to interferon treatment, which may be associated with an escape of tumor cells from immune surveillance. Therefore, the aim of this chapter is to summarize the frequency of impaired interferon signal transduction, their underlying molecular mechanisms, and their clinical relevance. Elsevier Inc. 2008 2020-08-17 /pmc/articles/PMC7125809/ /pubmed/19055946 http://dx.doi.org/10.1016/S0065-230X(08)00407-7 Text en Copyright © 2008 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Seliger, Barbara Ruiz‐Cabello, Francisco Garrido, Federico Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title | Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title_full | Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title_fullStr | Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title_full_unstemmed | Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title_short | Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors |
title_sort | chapter 7 ifn inducibility of major histocompatibility antigens in tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125809/ https://www.ncbi.nlm.nih.gov/pubmed/19055946 http://dx.doi.org/10.1016/S0065-230X(08)00407-7 |
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