Cargando…

N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

A series of phenyloxyethyl and cinnamyl derivatives of substituted uracils were synthesized and found to exhibit potent activity against HIV-RT and HIV replication in cell culture. In general, the cinnamyl derivatives proved superior to the phenyloxyethyl derivatives, however 1-[2-(4-methylphenoxy)e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Novikov, Mikhail S., Valuev-Elliston, Vladimir T., Babkov, Denis A., Paramonova, Maria P., Ivanov, Alexander V., Gavryushov, Sergey A, Khandazhinskaya, Anastasia L., Kochetkov, Sergey N., Pannecouque, Christophe, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125863/ https://www.ncbi.nlm.nih.gov/pubmed/23357038 http://dx.doi.org/10.1016/j.bmc.2012.12.027

Ejemplares similares

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
por: Novikov, Mikhail S., et al.
Publicado: (2013)

Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
por: Babkov, Denis A., et al.
Publicado: (2015)

1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents
por: Novikov, Mikhail S., et al.
Publicado: (2011)

Novel 1-[5-(4-bromophenoxy)pentyl]-3-(2-arylamino- 2-oxoethyl)uracils and their antiviral properties
por: Paramonova, Maria P., et al.
Publicado: (2017)

Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
por: Maslova, Anna A., et al.
Publicado: (2020)

A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides
por: Novikov, Mikhail S., et al.
Publicado: (2013)

Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives
por: Paramonova, M. P., et al.
Publicado: (2020)

New Derivatives of 5-Substituted Uracils: Potential Agents with a Wide Spectrum of Biological Activity
por: Kezin, Vasily A., et al.
Publicado: (2022)

2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
por: Babkov, D. A., et al.
Publicado: (2015)

Antiviral Activity of N(1),N(3)-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern
por: Siniavin, Andrei E., et al.
Publicado: (2022)

Synthesis of 3-hetarylpyrroles by Suzuki–Miyaura cross-coupling
por: Matyugina, Elena S., et al.
Publicado: (2020)

Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
por: Paramonova, M. P., et al.
Publicado: (2023)

5-Arylaminouracil Derivatives as Potential Dual-Action Agents
por: Matyugina, E. S., et al.
Publicado: (2015)

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2023)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2022)

Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2023)

Low rates of nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor drug resistance in Botswana
por: Moyo, Sikhulile, et al.
Publicado: (2019)

Potent Nonnucleoside Reverse Transcriptase Inhibitors Target HIV-1 Gag-Pol
por: Figueiredo, Anna, et al.
Publicado: (2006)

Synthesis, antiviral, cytotoxic and cytostatic evaluation of N(1)-(phosphonoalkyl)uracil derivatives
por: Rygielska-Tokarska, Dorota, et al.
Publicado: (2016)

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism
por: Das, Kalyan, et al.
Publicado: (2012)

The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors
por: Sluis-Cremer, Nicolas
Publicado: (2014)

Assessment of Nonnucleoside Inhibitors Binding to HIV-1 Reverse Transcriptase Using HYDE Scoring
por: Paneth, Agata, et al.
Publicado: (2019)

Investigation of the solvent-dependent photolysis of a nonnucleoside reverse-transcriptase inhibitor, antiviral agent efavirenz
por: Jordaan, Maryam A, et al.
Publicado: (2017)

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects
por: Cha, Yu-Jung, et al.
Publicado: (2014)

What do docking and QSAR tell us about the design of HIV-1 reverse transcriptase nonnucleoside inhibitors?
por: Paneth, Agata, et al.
Publicado: (2017)

Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV
por: Ankrom, Wendy, et al.
Publicado: (2021)

New Flexible Analogues of 8-Aza-7-deazapurine Nucleosides as Potential Antibacterial Agents
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2023)

Response to Therapy in Antiretroviral Therapy–Naive Patients With Isolated Nonnucleoside Reverse Transcriptase Inhibitor–Associated Transmitted Drug Resistance
por: Clutter, Dana S., et al.
Publicado: (2016)

Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy
por: Karamchand, Sumanth, et al.
Publicado: (2016)

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
por: Boyer, Paul L., et al.
Publicado: (2019)

Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replication
por: Magri, Andrea, et al.
Publicado: (2016)

Mechanistic Insights into the Photoisomerization of N,N′‐Disubstituted Indigos
por: Budzák, Šimon, et al.
Publicado: (2022)

Corrigendum: Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replication
por: Magri, Andrea, et al.
Publicado: (2016)

Dyslipidemia among HIV-infected Patients with Tuberculosis Taking Once-daily Nonnucleoside Reverse-Transcriptase Inhibitor–Based Antiretroviral Therapy in India
por: Padmapriyadarsini, Chandrasekaran, et al.
Publicado: (2011)

Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors
por: Liu, Genyan, et al.
Publicado: (2018)

Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK‐8507, an Investigational, Oral, Once‐Weekly Nonnucleoside Reverse Transcriptase Inhibitor
por: Gillespie, Gillian, et al.
Publicado: (2021)

Activation of Polyamine Catabolism by N(1),N(11)-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype
por: Ivanova, Olga N., et al.
Publicado: (2018)

Novel N,N′-Disubstituted Acylselenoureas as Potential Antioxidant and Cytotoxic Agents
por: Ruberte, Ana Carolina, et al.
Publicado: (2020)

Novel N,N′-Disubstituted Selenoureas as Potential Antioxidant and Cytotoxic Agents
por: Calvo-Martín, Gorka, et al.
Publicado: (2021)

Room-Temperature Spin Crossover in a Solution of Iron(II) Complexes with N,N′-Disubstituted Bis(pyrazol-3-yl)pyridines
por: Aleshin, Dmitry Yu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_crlf5kvqsm6tjrvennvj3bp6r3