Sendai virus in nude and germ-free rats

The pathogenesis of Sendai virus infection was studied in athymic and AGUS rats. The infection was more severe in the athymic rats and caused considerable clinical disease. Virus was shown to replicate in the bronchial epithelium and persisted in athymic rats for the duration of the experiment (32 d...

Descripción completa

Detalles Bibliográficos
Autores principales: Carthew, P., Sparrow, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1980
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125933/
https://www.ncbi.nlm.nih.gov/pubmed/6265992
http://dx.doi.org/10.1016/S0034-5288(18)32629-8
_version_ 1783516050000707584
author Carthew, P.
Sparrow, S.
author_facet Carthew, P.
Sparrow, S.
author_sort Carthew, P.
collection PubMed
description The pathogenesis of Sendai virus infection was studied in athymic and AGUS rats. The infection was more severe in the athymic rats and caused considerable clinical disease. Virus was shown to replicate in the bronchial epithelium and persisted in athymic rats for the duration of the experiment (32 days). The characteristic changes of necrosis of the bronchial epithelium and subsequent hyperplasia also persisted in this group and was accompanied by quite extensive interstitial pneumonitis. The virus failed to evoke an antibody response in the athymic rats.
format Online
Article
Text
id pubmed-7125933
institution National Center for Biotechnology Information
language English
publishDate 1980
publisher Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71259332020-04-08 Sendai virus in nude and germ-free rats Carthew, P. Sparrow, S. Res Vet Sci Article The pathogenesis of Sendai virus infection was studied in athymic and AGUS rats. The infection was more severe in the athymic rats and caused considerable clinical disease. Virus was shown to replicate in the bronchial epithelium and persisted in athymic rats for the duration of the experiment (32 days). The characteristic changes of necrosis of the bronchial epithelium and subsequent hyperplasia also persisted in this group and was accompanied by quite extensive interstitial pneumonitis. The virus failed to evoke an antibody response in the athymic rats. Published by Elsevier Ltd. 1980-11 2018-11-16 /pmc/articles/PMC7125933/ /pubmed/6265992 http://dx.doi.org/10.1016/S0034-5288(18)32629-8 Text en Copyright © 1980 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Carthew, P.
Sparrow, S.
Sendai virus in nude and germ-free rats
title Sendai virus in nude and germ-free rats
title_full Sendai virus in nude and germ-free rats
title_fullStr Sendai virus in nude and germ-free rats
title_full_unstemmed Sendai virus in nude and germ-free rats
title_short Sendai virus in nude and germ-free rats
title_sort sendai virus in nude and germ-free rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125933/
https://www.ncbi.nlm.nih.gov/pubmed/6265992
http://dx.doi.org/10.1016/S0034-5288(18)32629-8
work_keys_str_mv AT carthewp sendaivirusinnudeandgermfreerats
AT sparrows sendaivirusinnudeandgermfreerats

Ejemplares similares