Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis

A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and othe...

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Autores principales: Mlostoń, Grzegorz, Obijalska, Emilia, Heimgartner, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125969/
https://www.ncbi.nlm.nih.gov/pubmed/32287377
http://dx.doi.org/10.1016/j.jfluchem.2010.05.014
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author Mlostoń, Grzegorz
Obijalska, Emilia
Heimgartner, Heinz
author_facet Mlostoń, Grzegorz
Obijalska, Emilia
Heimgartner, Heinz
author_sort Mlostoń, Grzegorz
collection PubMed
description A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and other biologically active, fluorinated compounds are discussed. Attractive opportunities for their applications as organocatalysts are also presented.
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spelling pubmed-71259692020-04-06 Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis Mlostoń, Grzegorz Obijalska, Emilia Heimgartner, Heinz J Fluor Chem Review A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and other biologically active, fluorinated compounds are discussed. Attractive opportunities for their applications as organocatalysts are also presented. Elsevier B.V. 2010-08 2010-06-04 /pmc/articles/PMC7125969/ /pubmed/32287377 http://dx.doi.org/10.1016/j.jfluchem.2010.05.014 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Mlostoń, Grzegorz
Obijalska, Emilia
Heimgartner, Heinz
Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title_full Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title_fullStr Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title_full_unstemmed Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title_short Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
title_sort synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125969/
https://www.ncbi.nlm.nih.gov/pubmed/32287377
http://dx.doi.org/10.1016/j.jfluchem.2010.05.014
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