mRNA Cap-1 Methyltransferase in the SARS Genome

The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral the...

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Detalles Bibliográficos
Autores principales: von Grotthuss, Marcin, Wyrwicz, Lucjan S, Rychlewski, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press. Published by Elsevier Inc. 2003
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126025/
https://www.ncbi.nlm.nih.gov/pubmed/12809601
http://dx.doi.org/10.1016/S0092-8674(03)00424-0
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author von Grotthuss, Marcin
Wyrwicz, Lucjan S
Rychlewski, Leszek
author_facet von Grotthuss, Marcin
Wyrwicz, Lucjan S
Rychlewski, Leszek
author_sort von Grotthuss, Marcin
collection PubMed
description The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.
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spelling pubmed-71260252020-04-08 mRNA Cap-1 Methyltransferase in the SARS Genome von Grotthuss, Marcin Wyrwicz, Lucjan S Rychlewski, Leszek Cell Letter to the Editor The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy. Cell Press. Published by Elsevier Inc. 2003-06-13 2004-04-15 /pmc/articles/PMC7126025/ /pubmed/12809601 http://dx.doi.org/10.1016/S0092-8674(03)00424-0 Text en Copyright © 2003 Cell Press. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
von Grotthuss, Marcin
Wyrwicz, Lucjan S
Rychlewski, Leszek
mRNA Cap-1 Methyltransferase in the SARS Genome
title mRNA Cap-1 Methyltransferase in the SARS Genome
title_full mRNA Cap-1 Methyltransferase in the SARS Genome
title_fullStr mRNA Cap-1 Methyltransferase in the SARS Genome
title_full_unstemmed mRNA Cap-1 Methyltransferase in the SARS Genome
title_short mRNA Cap-1 Methyltransferase in the SARS Genome
title_sort mrna cap-1 methyltransferase in the sars genome
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126025/
https://www.ncbi.nlm.nih.gov/pubmed/12809601
http://dx.doi.org/10.1016/S0092-8674(03)00424-0
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